Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

Tuberculosis is primarily a respiratory disease that is caused by Mycobacterium
tuberculosis. M. tuberculosis can persist and replicate in macrophages in vivo, usually in …

Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …

Inflammatory skin conditions are increasingly recognised as being associated with systemic
inflammation. The mechanisms connecting the cutaneous and systemic disease are not well …

Abstract Mycobacterium bovis bacille Calmette-Guérin (BCG) prevents extrapulmonary
tuberculosis (TB) and death among infants but fails to consistently and sufficiently prevent …

Vaccination strategies against mycobacteria, focusing mostly on classical T‐and B‐cells,
have shown limited success, encouraging the addition of alternative targets. Classically …

The MR1 antigen-presenting system is conserved among mammals and enables T cells to
recognize small molecules produced by bacterial pathogens, including Mycobacterium …

Peptide-specific conventional T cells have been major targets for designing most
antimycobacterial vaccines. Immune responses mediated by conventional T cells exhibit a …

A majority of T cells bearing the αβ T cell receptor (TCR) are specific for peptides bound to
polymorphic classical major histocompatibility complex (MHC) molecules. Smaller subsets …

Tuberculosis is the most lethal infectious disease globally, but the vast majority of people
who are exposed to the primary causative pathogen, Mycobacterium tuberculosis (MTB), do …