The mechanobiology of endothelial-to-mesenchymal transition in cardiovascular disease
S Islam, KI Boström, D Di Carlo, CA Simmons… - Frontiers in …, 2021 - frontiersin.org
Endothelial cells (ECs) lining the cardiovascular system are subjected to a highly dynamic
microenvironment resulting from pulsatile pressure and circulating blood flow. Endothelial …
microenvironment resulting from pulsatile pressure and circulating blood flow. Endothelial …
FEBio FINESSE: An open-source finite element simulation approach to estimate in vivo heart valve strains using shape enforcement
DW Laurence, PM Sabin, AM Sulentic… - Annals of Biomedical …, 2024 - Springer
Purpose Finite element simulations are an enticing tool to evaluate heart valve function;
however, patient-specific simulations derived from 3D echocardiography are hampered by …
however, patient-specific simulations derived from 3D echocardiography are hampered by …
On valve interstitial cell signaling: the link between multiscale mechanics and mechanobiology
DP Howsmon, MS Sacks - Cardiovascular engineering and technology, 2021 - Springer
Heart valves function in one of the most mechanically demanding environments in the body
to ensure unidirectional blood flow. The resident valve interstitial cells respond to this …
to ensure unidirectional blood flow. The resident valve interstitial cells respond to this …
Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains
Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …
In vivo assessment of mitral valve leaflet remodelling following myocardial infarction
Abstract Each year, more than 40,000 people undergo mitral valve (MV) repair surgery
domestically to treat regurgitation caused by myocardial infarction (MI). Although continual …
domestically to treat regurgitation caused by myocardial infarction (MI). Although continual …
Simulation of mitral valve plasticity in response to myocardial infarction
Left ventricular myocardial infarction (MI) has broad and debilitating effects on cardiac
function. In many cases, MI leads to ischemic mitral regurgitation (IMR), a condition …
function. In many cases, MI leads to ischemic mitral regurgitation (IMR), a condition …
Bayesian Optimization-Based Inverse Finite Element Analysis for Atrioventricular Heart Valves
Inverse finite element analysis (iFEA) of the atrioventricular heart valves (AHVs) can provide
insights into the in-vivo valvular function, such as in-vivo tissue strains; however, there are …
insights into the in-vivo valvular function, such as in-vivo tissue strains; however, there are …
A Computational Pipeline for Patient-Specific Prediction of the Post-operative Mitral Valve Functional State
Mitral valve (MV) repair is safer than replacement for mitral regurgitation (MR) treatment, but
long-term outcomes remain suboptimal and poorly understood. Moreover, preoperative …
long-term outcomes remain suboptimal and poorly understood. Moreover, preoperative …
Alterations in human mitral valve mechanical properties secondary to left ventricular remodeling: a biaxial mechanical study
P Vandemaele, K Vander Linden, S Deferm… - Frontiers in …, 2022 - frontiersin.org
Secondary mitral regurgitation occurs when a left ventricular problem causes leaking of the
mitral valve. The altered left ventricular geometry changes the orientation of the subvalvular …
mitral valve. The altered left ventricular geometry changes the orientation of the subvalvular …
Mitral regurgitation severity at left ventricular assist device implantation is associated with distinct myocardial transcriptomic signatures
Objectives We examined for differences in pre–left ventricular assist device (LVAD)
implantation myocardial transcriptome signatures among patients with different degrees of …
implantation myocardial transcriptome signatures among patients with different degrees of …