HIV-associated cryptococcal meningitis is by far the most common cause of adult meningitis
in many areas of the world that have high HIV seroprevalence. In most areas in Sub …

Nearly 30 years after the advent of antiretroviral therapy (ART), CNS opportunistic infections
remain a major cause of morbidity and mortality in HIV-positive individuals. Unknown HIV …

The outcome of cryptococcal pneumonia correlates with local macrophage polarization
status, as M1 and M2 polarization marks protective and nonprotective responses …

Dendritic cells (DCs), a vital component of the innate immune system, are considered to lack
antigen specificity and be devoid of immunological memory. Strategies that can induce …

Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

Background: Interferon-gamma (IFNγ) is of key importance in the immune response to
Cryptococcus neoformans. Mortality related to cryptococcal meningitis remains high, and …

Macrophages are innate immune cells that possess unique abilities to polarize toward
different phenotypes. Classically activated macrophages are known to have major roles in …

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological
studies of human populations show a high prevalence of human infection, which rarely …

The immune response to Cryptococcus neoformans following pulmonary infection of
C57BL/6 wild-type (WT) mice results in the development of persistent infection with …

Cryptococcus neoformans is a major fungal pathogen that disseminates to the central
nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune …