[HTML][HTML] Structural hallmarks of lung surfactant: Lipid-protein interactions, membrane structure and future challenges
JC Castillo-Sánchez, A Cruz, J Pérez-Gil - Archives of biochemistry and …, 2021 - Elsevier
Lung surfactant (LS) is an outstanding example of how a highly regulated and dynamic
membrane-based system has evolved to sustain a wealth of structural reorganizations in …
membrane-based system has evolved to sustain a wealth of structural reorganizations in …
Evolution of interfacial mechanics of lung surfactant mimics progression of acute respiratory distress syndrome
CO Ciutara, SV Iasella, B Huang… - Proceedings of the …, 2023 - National Acad Sciences
How acute respiratory distress syndrome progresses from underlying disease or trauma is
poorly understood, and there are no generally accepted treatments resulting in a 40 …
poorly understood, and there are no generally accepted treatments resulting in a 40 …
Inflammation product effects on dilatational mechanics can trigger the Laplace instability and acute respiratory distress syndrome
In the lungs, the Laplace pressure, ΔP= 2γ/R, would be higher in smaller alveoli than larger
alveoli unless the surface tension, γ decreases with alveolar interfacial area, A, such that 2ε> …
alveoli unless the surface tension, γ decreases with alveolar interfacial area, A, such that 2ε> …
Visualizing monolayers with a water-soluble fluorophore to quantify adsorption, desorption, and the double layer
IC Shieh, JA Zasadzinski - Proceedings of the National …, 2015 - National Acad Sciences
Contrast in confocal microscopy of phase-separated monolayers at the air–water interface
can be generated by the selective adsorption of water-soluble fluorescent dyes to …
can be generated by the selective adsorption of water-soluble fluorescent dyes to …
Transient exposure of pulmonary surfactant to hyaluronan promotes structural and compositional transformations into a highly active state
E Lopez-Rodriguez, A Cruz, RP Richter… - Journal of Biological …, 2013 - ASBMB
Pulmonary surfactant is a lipid-protein complex that lowers surface tension at the respiratory
air-liquid interface, stabilizing the lungs against physical forces tending to collapse alveoli …
air-liquid interface, stabilizing the lungs against physical forces tending to collapse alveoli …
Microtensiometer for confocal microscopy visualization of dynamic interfaces
Adsorption of surface-active molecules to fluid-fluid interfaces is ubiquitous in nature.
Characterizing these interfaces requires measuring surfactant adsorption rates, evaluating …
Characterizing these interfaces requires measuring surfactant adsorption rates, evaluating …
Development of model diblock copolymer surfactants for mechanistic investigations of cell membrane stabilization
KJ Haman - 2015 - search.proquest.com
Amphiphilic triblock copolymers of poly (ethylene oxide) and poly (propylene oxide),
generically referred to as poloxamers, have been identified for therapeutic use in cell …
generically referred to as poloxamers, have been identified for therapeutic use in cell …
Irremovable Blood Stain in Lung: Air-to-Interface Transport of Albumin and Its Mechanical Response to Biaxial Compression/Expansion
Serum proteins are believed to trigger a sudden failure of lung function, but to date the
mechanism remains elusive. Most studies have focused on the transport of the proteins from …
mechanism remains elusive. Most studies have focused on the transport of the proteins from …
Analytical Techniques for Evaluating Protein Instability at Interfaces
IC Shieh, Y Cheng - Protein Instability at Interfaces During Drug Product …, 2021 - Springer
Proteins at interfaces present a number of analytical challenges, particularly in the context of
biotherapeutic formulations. Proteins typically adsorb to interfaces in thin films or …
biotherapeutic formulations. Proteins typically adsorb to interfaces in thin films or …
[图书][B] Three-dimensional visualization of interfacial phenomena using confocal microscopy
IC Shieh - 2012 - search.proquest.com
Surfactants play an integral role in numerous functions ranging from stabilizing the emulsion
in a favorite salad dressing to organizing the cellular components that make life possible …
in a favorite salad dressing to organizing the cellular components that make life possible …