The gut-liver axis in liver disease: Pathophysiological basis for therapy

A Albillos, A De Gottardi, M Rescigno - Journal of hepatology, 2020 - Elsevier
The gut-liver axis refers to the bidirectional relationship between the gut and its microbiota,
and the liver, resulting from the integration of signals generated by dietary, genetic and …

Gut–liver axis in alcoholic liver disease

G Szabo - Gastroenterology, 2015 - Elsevier
Alcoholic liver disease (ALD) has been among the leading causes of cirrhosis and liver-
related death worldwide for decades. Early discoveries in alcoholic liver disease identified …

Gut microbiome as a therapeutic target for liver diseases

TP Singh, S Kadyan, H Devi, G Park, R Nagpal - Life Sciences, 2023 - Elsevier
The prominent role of gut in regulating the physiology of different organs in a human body is
increasingly acknowledged, to which the bidirectional communication between gut and liver …

CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT

MF Mohamed, K Gupta, JW Goldufsky, R Roy… - Nature …, 2022 - nature.com
Abstract Type 3 Secretion System (T3SS) is a highly conserved virulence structure that plays
an essential role in the pathogenesis of many Gram-negative pathogenic bacteria, including …

Vinegar extract ameliorates alcohol-induced liver damage associated with the modulation of gut microbiota in mice

T Xia, B Zhang, S Li, B Fang, W Duan, J Zhang… - Food & function, 2020 - pubs.rsc.org
Vinegar extract is rich in phenolic compounds, which can prevent free radical-induced
diseases. The aim of the present study was to explore the effects of vinegar extract on gut …

[HTML][HTML] Faecal cytokine profiling as a marker of intestinal inflammation in acutely decompensated cirrhosis

A Riva, EH Gray, S Azarian, A Zamalloa, MJW McPhail… - JHEP reports, 2020 - Elsevier
Background & Aims Gut dysbiosis and inflammation perpetuate loss of gut barrier integrity
(GBI) and pathological bacterial translocation (BT) in cirrhosis, contributing to infection risk …

Pseudomonas aeruginosa ExoT induces mitochondrial apoptosis in target host cells in a manner that depends on its GTPase-activating protein (GAP) domain activity

SJ Wood, JW Goldufsky, D Bello, S Masood… - Journal of Biological …, 2015 - ASBMB
Pseudomonas aeruginosa is the most common cause of hospital-acquired pneumonia and
a killer of immunocompromised patients. We and others have demonstrated that the type III …

Akkermansia muciniphila Ameliorates Alcoholic Liver Disease in Experimental Mice by Regulating Serum Metabolism and Improving Gut Dysbiosis

C Fang, J Cheng, W Jia, Y Xu - Metabolites, 2023 - mdpi.com
Alcoholic liver disease (ALD) represents a significant global health concern, yet the
available treatment options remain limited. Numerous studies have shown that gut …

Apoptosis and compensatory proliferation signaling are coupled by CrkI-containing microvesicles

KH Gupta, JW Goldufsky, SJ Wood, NJ Tardi… - Developmental cell, 2017 - cell.com
Apoptosis has been implicated in compensatory proliferation signaling (CPS), whereby
dying cells induce proliferation in neighboring cells as a means to restore homeostasis. The …

The role of the microbiome in liver cancer

M Moreno-Gonzalez, N Beraza - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is the most common primary liver cancer
and the fourth most common cause of cancer-related deaths worldwide; its incidence and …