Hypervalent iodine (III) compounds have found wide application in modern organic
chemistry as environmentally friendly reagents and catalysts. Hypervalent iodine reagents …

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …

Fluorinated small molecules are prevalent across the functional small-molecule spectrum,
but the scarcity of naturally occurring sources creates an opportunity for creative endeavour …

Herein, we report a modular catalytic technique that streamlines the preparation of gem-
difluoroalkanes from unactivated sp 3 precursors. The method is characterized by its …

The clinical success of α, α-difluorocyclopropanes, combined with limitations in the existing
synthesis portfolio, inspired the development of an operationally simple, organocatalysis …

Short aliphatic groups are prevalent in bioactive small molecules and play an essential role
in regulating physicochemistry and molecular recognition phenomena. Delineating their …

The regio‐and enantio‐selective, intermolecular vicinal fluoroamination of α‐trifluoromethyl
styrenes has been achieved by enantioselective II/IIII catalysis. Leveraging C2‐symmetric …

Abstract A catalysis‐based regioselective 1, 4‐fluorofunctionalization of trifluoromethyl
substituted 1, 3‐dienes has been developed to access compact, highly functionalized …

Partially saturated, fluorine-containing rings are ubiquitous across the drug discovery
spectrum. This capitalises upon the biological significance of the native structure and the …

Cyclic β, β‐difluoro‐carbonyl compounds have a venerable history as drug discovery leads,
but limitations in the synthesis arsenal continue to impede chemical space exploration. This …