The uptake of metal–organic frameworks: A journey into the cell

E Linnane, S Haddad, F Melle, Z Mei… - Chemical Society …, 2022 - pubs.rsc.org
The application of metal–organic frameworks (MOFs) in drug delivery has advanced rapidly
over the past decade, showing huge progress in the development of novel systems …

Metal–organic framework composites for theragnostics and drug delivery applications

JWM Osterrieth, D Fairen‐Jimenez - Biotechnology Journal, 2021 - Wiley Online Library
Among a plethora of nano‐sized therapeutics, metal‐organic frameworks (MOFs) have been
some of the most investigated novel materials for, predominantly, cancer drug delivery …

Non-viral gene therapy: Gains and challenges of non-invasive administration methods

M Foldvari, DW Chen, N Nafissi, D Calderon… - Journal of Controlled …, 2016 - Elsevier
Gene therapy is becoming an influential part of the rapidly increasing armamentarium of
biopharmaceuticals for improving health and combating diseases. Currently, three gene …

Chemical modifications of nucleic acid drugs and their delivery systems for gene‐based therapy

C Chen, Z Yang, X Tang - Medicinal research reviews, 2018 - Wiley Online Library
Gene‐based therapy is one of essential therapeutic strategies for precision medicine
through targeting specific genes in specific cells of target tissues. However, there still exist …

[HTML][HTML] The role of microRNA in the pathogenesis of glial brain tumors

O Beylerli, I Gareev, A Sufianov, T Ilyasova… - Non-coding RNA …, 2022 - Elsevier
Gliomas are the most common and fatal primary brain tumor in adults. Gliomas are highly
invasive tumors with the highest mortality among all primary malignant brain tumors. Until …

[HTML][HTML] Metal-organic framework nanoparticle-based biomineralization: a new strategy toward cancer treatment

C Chu, M Su, J Zhu, D Li, H Cheng, X Chen, G Liu - Theranostics, 2019 - ncbi.nlm.nih.gov
Cancer treatment using functional proteins, DNA/RNA, or complex bio-entities is important in
both preclinical and clinical studies. With the help of nano-delivery systems, these …

Cholesterol-mediated seeding of protein corona on DNA nanostructures for targeted delivery of oligonucleotide therapeutics to treat liver fibrosis

KR Kim, J Kim, JH Back, JE Lee, DR Ahn - ACS nano, 2022 - ACS Publications
The protein corona is a protein layer formed on the surface of nanoparticles administered in
vivo and considerably affects the in vivo fate of nanoparticles. Although it is challenging to …

[HTML][HTML] Oral delivery of non-viral nucleic acid-based therapeutics-do we have the guts for this?

CM O'Driscoll, A Bernkop-Schnürch, JD Friedl… - European Journal of …, 2019 - Elsevier
Gene therapy with RNA and pDNA-based drugs is limited by poor enzymatic stability and
poor cellular permeation. The delivery of nucleic acids, in particular by the oral route …

Targeting MMP-9 in diabetic foot ulcers

JI Jones, TT Nguyen, Z Peng, M Chang - Pharmaceuticals, 2019 - mdpi.com
Diabetic foot ulcers (DFUs) are significant complications of diabetes and an unmet medical
need. Matrix metalloproteinases (MMPs) play important roles in the pathology of wounds …

Nucleic acid-binding dyes as versatile photocatalysts for atom-transfer radical polymerization

J Jeong, X Hu, R Yin, M Fantin, SR Das… - Journal of the …, 2024 - ACS Publications
Nucleic acid-binding dyes (NuABDs) are fluorogenic probes that light up after binding to
nucleic acids. Taking advantage of their fluorogenicity, NuABDs have been widely utilized in …