The uptake of metal–organic frameworks: A journey into the cell
The application of metal–organic frameworks (MOFs) in drug delivery has advanced rapidly
over the past decade, showing huge progress in the development of novel systems …
over the past decade, showing huge progress in the development of novel systems …
Metal–organic framework composites for theragnostics and drug delivery applications
JWM Osterrieth, D Fairen‐Jimenez - Biotechnology Journal, 2021 - Wiley Online Library
Among a plethora of nano‐sized therapeutics, metal‐organic frameworks (MOFs) have been
some of the most investigated novel materials for, predominantly, cancer drug delivery …
some of the most investigated novel materials for, predominantly, cancer drug delivery …
Non-viral gene therapy: Gains and challenges of non-invasive administration methods
M Foldvari, DW Chen, N Nafissi, D Calderon… - Journal of Controlled …, 2016 - Elsevier
Gene therapy is becoming an influential part of the rapidly increasing armamentarium of
biopharmaceuticals for improving health and combating diseases. Currently, three gene …
biopharmaceuticals for improving health and combating diseases. Currently, three gene …
Chemical modifications of nucleic acid drugs and their delivery systems for gene‐based therapy
C Chen, Z Yang, X Tang - Medicinal research reviews, 2018 - Wiley Online Library
Gene‐based therapy is one of essential therapeutic strategies for precision medicine
through targeting specific genes in specific cells of target tissues. However, there still exist …
through targeting specific genes in specific cells of target tissues. However, there still exist …
[HTML][HTML] The role of microRNA in the pathogenesis of glial brain tumors
O Beylerli, I Gareev, A Sufianov, T Ilyasova… - Non-coding RNA …, 2022 - Elsevier
Gliomas are the most common and fatal primary brain tumor in adults. Gliomas are highly
invasive tumors with the highest mortality among all primary malignant brain tumors. Until …
invasive tumors with the highest mortality among all primary malignant brain tumors. Until …
[HTML][HTML] Metal-organic framework nanoparticle-based biomineralization: a new strategy toward cancer treatment
Cancer treatment using functional proteins, DNA/RNA, or complex bio-entities is important in
both preclinical and clinical studies. With the help of nano-delivery systems, these …
both preclinical and clinical studies. With the help of nano-delivery systems, these …
Cholesterol-mediated seeding of protein corona on DNA nanostructures for targeted delivery of oligonucleotide therapeutics to treat liver fibrosis
The protein corona is a protein layer formed on the surface of nanoparticles administered in
vivo and considerably affects the in vivo fate of nanoparticles. Although it is challenging to …
vivo and considerably affects the in vivo fate of nanoparticles. Although it is challenging to …
[HTML][HTML] Oral delivery of non-viral nucleic acid-based therapeutics-do we have the guts for this?
Gene therapy with RNA and pDNA-based drugs is limited by poor enzymatic stability and
poor cellular permeation. The delivery of nucleic acids, in particular by the oral route …
poor cellular permeation. The delivery of nucleic acids, in particular by the oral route …
Targeting MMP-9 in diabetic foot ulcers
Diabetic foot ulcers (DFUs) are significant complications of diabetes and an unmet medical
need. Matrix metalloproteinases (MMPs) play important roles in the pathology of wounds …
need. Matrix metalloproteinases (MMPs) play important roles in the pathology of wounds …
Nucleic acid-binding dyes as versatile photocatalysts for atom-transfer radical polymerization
Nucleic acid-binding dyes (NuABDs) are fluorogenic probes that light up after binding to
nucleic acids. Taking advantage of their fluorogenicity, NuABDs have been widely utilized in …
nucleic acids. Taking advantage of their fluorogenicity, NuABDs have been widely utilized in …