Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities

Q Pei, Q Yi, L Tang - International Journal of Molecular Sciences, 2023 - mdpi.com
The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …

Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma

L Qu, Y Liu, J Deng, X Ma, D Fan - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Ginsenoside Rk3, an important and rare saponin in heat-treated ginseng, is generated from …

Efficacy and safety of glycyrrhizic acid preparation treating comorbid liver injury in COVID-19: A systematic review

X Liu, X Tian, Z Ma, J Chen, Q Huang, P Gao… - Frontiers in …, 2022 - frontiersin.org
Background: No specific drug for COVID-19 has been found, and many studies have found
that different degrees of liver injury often occurred after infection with COVID-19. Glycyrrhizic …

Prussian blue nanohybridized multicellular spheroids as composite engraftment for antioxidant bone regeneration and photoacoustic tomography

L Chen, S Tang, J Zhang, C Zhong, X Xu, J Yan, K Hu… - ACS …, 2024 - ACS Publications
Regulating the complex microenvironment after tooth extraction to promote alveolar bone
regeneration is a pressing challenge for restorative dentistry. In this study, through …

[HTML][HTML] Furanodienone induces apoptosis via regulating the PRDX1/MAPKs/p53/caspases signaling axis through NOX4-derived mitochondrial ROS in colorectal …

Y Jiang, Y Li, Y Wang, X Li - Biochemical Pharmacology, 2024 - Elsevier
Furanodienone, a biologically active constituent of sesquiterpenes isolated from Rhizome
Curcumae, has been reported to induce apoptosis in human colorectal cancer (CRC) cells …

Glycyrrhizic acid ameliorates hepatic fibrosis by inhibiting oxidative stress via AKR7A2

Q Wang, T Lu, P Song, Y Dong, C Dai, W Zhang, X Jia… - Phytomedicine, 2024 - Elsevier
Background Hepatic fibrosis is a reversible pathological phenomenon caused by the
abnormal proliferation of connective tissues in the liver for self-repair after persistent liver …

[HTML][HTML] Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis

L Lin, X Li, Y Li, Z Lang, Y Li, J Zheng - Journal of Pharmaceutical Analysis, 2024 - Elsevier
Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), a process
associated with ferroptosis. Ginsenoside Rb1 (GRb1), a major active component extracted …

Triterpene-Based Prodrug for Self-Boosted Drug Release and Targeted Oral Squamous Cell Carcinoma Chemotherapy

J Zhong, G He, X Ma, J Ye, ZY Tao, Z Li… - … Applied Materials & …, 2024 - ACS Publications
Chemotherapy is one of the main treatments for oral squamous cell carcinoma (OSCC),
especially as a combined modality approach with and after surgery or radiotherapy. Limited …

18β-Glycyrrhetinic Acid Mitigates Bisphenol A-induced Liver and Renal Damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 Pathways, Oxidative Stress and …

E Darendelioglu, C Caglayan, S Küçükler… - Food and Chemical …, 2024 - Elsevier
Bisphenol A (BPA) has been commonly used in various consumer products, including water
bottles, food containers, and canned food linings. However, there are concerns about its …

Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening

ML Luo, H Chen, GY Chen, S Wang, Y Wang, FQ Yang - Molecules, 2023 - mdpi.com
A biomimetic mineralization method was used in the facile and rapid preparation of
nanoflowers for immobilizing alcohol dehydrogenase (ADH). The method mainly uses ADH …