Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity

PV Markov, A Katzourakis, NI Stilianakis - Nature Reviews Microbiology, 2022 - nature.com
The comparatively milder infections with the Omicron variant and higher levels of population
immunity have raised hopes for a weakening of the pandemic. We argue that the lower …

Towards SARS-CoV-2 serotypes?

E Simon-Loriere, O Schwartz - Nature Reviews Microbiology, 2022 - nature.com
The magnitude of immune evasion of Omicron raises the question whether it should be
considered as a distinct SARS-CoV-2 serotype. Here, we discuss lines of evidence in …

[HTML][HTML] Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Q Wang, S Iketani, Z Li, L Liu, Y Guo, Y Huang… - Cell, 2023 - cell.com
The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly
due to altered antibody evasion properties deriving from their additional spike mutations …

Antigenic cartography of SARS-CoV-2 reveals that Omicron BA. 1 and BA. 2 are antigenically distinct

AZ Mykytyn, M Rissmann, A Kok, ME Rosu… - Science …, 2022 - science.org
The emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy
substantially. The Omicron variant termed BA. 2, which differs substantially from BA. 1 based …

[HTML][HTML] Humoral immune escape by current SARS-CoV-2 variants BA. 2.86 and JN. 1, December 2023

LM Jeworowski, B Mühlemann, F Walper… - …, 2024 - eurosurveillance.org
Variant BA. 2.86 and its descendant, JN. 1, of SARS-CoV-2 are rising in incidence across
Europe and globally. We isolated recent JN. 1, BA. 2.86, EG. 5, XBB. 1.5 and earlier variants …

Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA. 1 and BA. 2 by convalescent and vaccine serum and monoclonal antibodies

A Wilhelm, M Widera, K Grikscheit, T Toptan… - …, 2022 - thelancet.com
Summary Background In recent months, Omicron variants of SARS-CoV-2 have become
dominant in many regions of the world, and case numbers with Omicron subvariants BA. 1 …

Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial

AR Branche, NG Rouphael, DJ Diemert, AR Falsey… - Nature medicine, 2023 - nature.com
Vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection wanes over time, requiring updated boosters. In a phase 2, open-label, randomized …

Antigenic cartography using sera from sequence-confirmed SARS-CoV-2 variants of concern infections reveals antigenic divergence of Omicron

K van der Straten, D Guerra, MJ van Gils, I Bontjer… - Immunity, 2022 - cell.com
Large-scale vaccination campaigns have prevented countless hospitalizations and deaths
due to COVID-19. However, the emergence of SARS-CoV-2 variants that escape from …

BA. 2 and BA. 5 omicron differ immunologically from both BA. 1 omicron and pre-omicron variants

A Rössler, A Netzl, L Knabl, H Schäfer, SH Wilks… - Nature …, 2022 - nature.com
Several studies have shown that SARS-CoV-2 BA. 1 omicron is an immune escape variant.
Meanwhile, however, omicron BA. 2 and BA. 5 became dominant in many countries and …

SARS-CoV-2 correlates of protection from infection against variants of concern

K Sun, JN Bhiman, S Tempia, J Kleynhans… - Nature Medicine, 2024 - nature.com
Serum neutralizing antibodies (nAbs) induced by vaccination have been linked to protection
against symptomatic and severe coronavirus disease 2019. However, much less is known …