Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow …

Simple Summary B cells are an essential component of the immune system and develop in
the bone marrow microenvironment. B-cell development is tightly regulated by the stromal …

In recent decades, the conduct of uniform prospective clinical trials has led to improved
remission rates and survival for patients with acute myeloid leukaemia and acute …

Parthenolide (PTL or PAR) was first isolated from Magnolia grandiflora and identified as a
small molecule cancer inhibitor. PTL has the chemical structure of C15H20O3 with …

StemDriver is a comprehensive knowledgebase dedicated to the functional annotation of
genes participating in the determination of hematopoietic stem cell fate, available at …

Acute lymphoblastic leukemia (ALL) is a malignancy with high heterogeneity in its biological
features and treatments. Although the overall survival (OS) of patients with ALL has recently …

Components of the bone marrow microenvironment (BMM) have been shown to mediate the
way in which leukemia develops, progresses and responds to treatment. Increasing …

Leukemias are refractory hematological malignancies, characterized by marked intrinsic
heterogeneity which poses significant obstacles to effective treatment. However, traditional …

Leukemic cell growth in the bone marrow (BM) induces a very stressful condition.
Mesenchymal stem cells (MSC), a key component of this BM niche, are affected in several …