Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …

Biguanides are compounds in which two guanidine moieties are fused to form a highly
conjugated system. Biguanides are highly basic and hence they are available as salts …

According to the World Health Organization, the population of over 60 will double in the next
30 years in the developed countries, which will enforce a further raise of the retirement age …

OBJECTIVE The aim of this study was to describe cross-sectional and longitudinal
associations between glycated hemoglobin (HbA1c) levels and strategies to control type 2 …

We studied whether in patients with COPD the use of metformin for diabetes treatment was
linked to a pattern of lung function decline consistent with the hypothesis of anti-aging effects …

Metformin has been used clinically for more than 60 years. As time goes by, more and more
miraculous effects of metformin beyond the clinic have been discovered and discussed. In …

Skeletal muscle is the largest tissue in the body, and plays a remarkable role in energy and
metabolic homeostasis. Disorder in lipid metabolism and glucose utilization could impair the …

Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disorder that is associated with
the accumulation of triglycerides (TG) in hepatocytes. Resveratrol (RSV), as a natural …

Here, through this review, we aim to serve this purpose by first discussing the statistics and
aging demographics, including the life expectancy of the world and India, along with the …