At sites of vascular injury, platelets come into contact with subendothelial collagen, which
triggers their activation and the formation of a hemostatic plug. Besides glycoprotein Ib …

Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble
scaffold which is essential for tissue integrity and which provides a surface for the …

Platelet function mediates both beneficial and harmful effects on human health, but few
genes are known to contribute to variability in this process. We tested association of 2.5 …

Glycoprotein (GP) VI is a platelet membrane protein with a molecular weight of 62 kDa that
was identified as a physiological collagen receptor from studies of patients deficient in this …

We have investigated the density of the collagen receptors glycoprotein VI (GPVI) and α2β1
on human platelets and their relationship to polymorphisms within the GPVI gene. GPVI …

Human patients with defects associated with the platelet collagen receptor, glycoprotein
(GP) VI, are rare and usually described as having a mild bleeding disorder. However, here …

Platelet glycoprotein (GP) VI is a 62-kDa membrane glycoprotein that exists on both human
and murine platelets in a noncovalent complex with the Fc receptor (FcR) γ chain. The …

interactions, because monozygotic twins share 100% of their genes, whereas dizygotic twins
on average share only 50% of their genome. Genetic model fitting showed that gene coding …

Interaction of platelets with collagen under conditions of blood flow is a multi-step process
with tethering via glycoprotein IbIXV (GPIbIXV) over von Willebrand factor, adhesion by …

Background—We studied the role of glycoprotein (GP) VI in platelet adhesion and thrombus
formation on the immobilized collagen and von Willebrand factor (vWF) surface under flow …