Monocytes are innate immune cells of the mononuclear phagocyte system that have
emerged as important regulators of cancer development and progression. Our …

Cancer is the leading disease-related cause of death in children in developed countries.
Arising in the context of actively growing tissues, childhood cancers are fundamentally …

Circulating monocytes can compete for virtually any tissue macrophage niche and become
long-lived replacements that are phenotypically indistinguishable from their embryonic …

Inflammation of the nervous system (neuroinflammation) is now recognized as a hallmark of
virtually all neurological disorders. In neuroinflammatory conditions such as multiple …

Millions of cancer survivors experience a persistent neurological syndrome that includes
deficits in memory, attention, information processing, and mental health. Cancer therapy …

Renal macrophages (RMs) participate in tissue homeostasis, inflammation and repair. RMs
consist of embryo-derived (EMRMs) and bone marrow-derived RMs (BMRMs), but the fate …

Up to 85% of adult cancer survivors and 99% of adult survivors of childhood cancer live with
an accumulation of chronic conditions, frailty, and/or cognitive impairments resulting from …

Cognitive dysfunction is a challenging adverse effect of chemotherapy and radiotherapy that
has limited treatment options. Clinical trials for proposed pharmacotherapeutic interventions …

Radiation-induced brain injury (RIBI) after radiotherapy has become an increasingly
important factor affecting the prognosis of patients with head and neck tumor. With the …

Amyotrophic lateral sclerosis (ALS) is a chronic, progressive neurodegenerative disease
characterized by the loss of motor neurons. Dysregulated peripheral immunity has been …