Matching the power of high throughput screening to the chemical diversity of natural products
CJ Henrich, JA Beutler - Natural product reports, 2013 - pubs.rsc.org
Matching the power of high throughput screening to the chemical diversity of natural products -
Natural Product Reports (RSC Publishing) DOI:10.1039/C3NP70052F Royal Society of …
Natural Product Reports (RSC Publishing) DOI:10.1039/C3NP70052F Royal Society of …
Natural products as a foundation for drug discovery
JA Beutler - Current protocols in pharmacology, 2019 - Wiley Online Library
Many natural products have been used as drugs for the treatment of diverse indications.
Although most US pharmaceutical companies have reduced or eliminated their inhouse …
Although most US pharmaceutical companies have reduced or eliminated their inhouse …
Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3
JA Galan, KM Geraghty, G Lavoie… - Proceedings of the …, 2014 - National Acad Sciences
The Ras/MAPK signaling cascade regulates various biological functions, including cell
growth and proliferation. As such, this pathway is frequently deregulated in several types of …
growth and proliferation. As such, this pathway is frequently deregulated in several types of …
[HTML][HTML] Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis
Background Chronic Lymphocytic Leukemia (CLL) pathogenesis has been linked to the
prolonged survival and/or apoptotic resistance of leukemic B cells in vivo, and is thought to …
prolonged survival and/or apoptotic resistance of leukemic B cells in vivo, and is thought to …
[HTML][HTML] Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1
JS Blees, HR Bokesch, D Rübsamen, K Schulz, L Milke… - 2012 - journals.plos.org
Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as
a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 …
a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 …
Cryptocaryols A–H, α-Pyrone-Containing 1,3-Polyols from Cryptocarya sp. Implicated in Stabilizing the Tumor Suppressor Pdcd4
T Grkovic, JS Blees, NH Colburn, T Schmid… - Journal of natural …, 2011 - ACS Publications
A high-throughput cell-based reporter assay designed to identify small-molecule stabilizers
of the tumor suppressor Pdcd4 was used to screen extracts in the NCI Natural Products …
of the tumor suppressor Pdcd4 was used to screen extracts in the NCI Natural Products …
Actinopolysporins A–C and Tubercidin as a Pdcd4 Stabilizer from the Halophilic Actinomycete Actinopolyspora erythraea YIM 90600
LX Zhao, SX Huang, SK Tang, CL Jiang… - Journal of natural …, 2011 - ACS Publications
Our current natural product program utilizes new actinomycetes originating from unexplored
and underexplored ecological niches, employing cytotoxicity against a selected panel of …
and underexplored ecological niches, employing cytotoxicity against a selected panel of …
[HTML][HTML] Have tumor suppressor PDCD4 and its counteragent oncogenic miR-21 gone rogue?
MR Young, AN Santhanam, N Yoshikawa… - Molecular …, 2010 - ncbi.nlm.nih.gov
A recent article suggests that the well known tumor suppressor PDCD4 also functions as a
pro-inflammatory agent. The PDCD4 counteragent miR-21, a pro-oncogenic micro-RNA, is …
pro-inflammatory agent. The PDCD4 counteragent miR-21, a pro-oncogenic micro-RNA, is …
Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation
T Schmid, MM Bajer, JS Blees, LK Eifler, L Milke… - …, 2011 - academic.oup.com
The tumor suppressor programmed cell death 4 (Pdcd4) is lost in various tumor tissues.
Loss of Pdcd4 has been associated with increased tumorigenic potential and tumor …
Loss of Pdcd4 has been associated with increased tumorigenic potential and tumor …
[HTML][HTML] Tricyclic Guanidine Alkaloids from the Marine Sponge Acanthella cavernosa that Stabilize the Tumor Suppressor PDCD4
T Grkovic, JS Blees, MM Bayer, NH Colburn… - Marine drugs, 2014 - mdpi.com
A cell-based high-throughput screen that assessed the cellular stability of a tumor
suppressor protein PDCD4 (Programmed cell death 4) was used to identify a new guanidine …
suppressor protein PDCD4 (Programmed cell death 4) was used to identify a new guanidine …