DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
The genetic basis of major depression
KM Kendall, E Van Assche, TFM Andlauer… - Psychological …, 2021 - cambridge.org
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
[HTML][HTML] Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder
Inflammatory processes are implicated in the aetiology of Major Depressive Disorder (MDD);
however, the relationship between peripheral inflammation, brain structure and depression …
however, the relationship between peripheral inflammation, brain structure and depression …
Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of …
Background Childhood adversity is a potent determinant of health across development and
is associated with altered DNA methylation signatures, which might be more common in …
is associated with altered DNA methylation signatures, which might be more common in …
[HTML][HTML] Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of …
Alcohol misuse is common in many societies worldwide and is associated with extensive
morbidity and mortality, often leading to alcohol use disorders (AUD) and alcohol-related …
morbidity and mortality, often leading to alcohol use disorders (AUD) and alcohol-related …
[HTML][HTML] An overview of DNA methylation-derived trait score methods and applications
Microarray technology has been used to measure genome-wide DNA methylation in
thousands of individuals. These studies typically test the associations between individual …
thousands of individuals. These studies typically test the associations between individual …
[HTML][HTML] Local CpG density affects the trajectory and variance of age-associated DNA methylation changes
Background DNA methylation is an epigenetic mark associated with the repression of gene
promoters. Its pattern in the genome is disrupted with age and these changes can be used to …
promoters. Its pattern in the genome is disrupted with age and these changes can be used to …
[HTML][HTML] Metabolomic investigation of major depressive disorder identifies a potentially causal association with polyunsaturated fatty acids
Background Metabolic differences have been reported between individuals with and without
major depressive disorder (MDD), but their consistency and causal relevance have been …
major depressive disorder (MDD), but their consistency and causal relevance have been …
[HTML][HTML] Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L.
R Matraszek-Gawron, M Chwil, K Terlecki… - Pharmaceuticals, 2022 - mdpi.com
Psychotropic effect of Crocus sativus L.(family Iridaceae) biologically active chemical
compounds are quite well documented and they can therefore be used in addition to the …
compounds are quite well documented and they can therefore be used in addition to the …
Molecular mechanisms underlying major depressive disorder and post-stroke affective disorders
D Colita, D Burdusel, D Glavan, DM Hermann… - Journal of Affective …, 2023 - Elsevier
Two of the most common and incapacitating mental health disorders around the world are
major depressive disorder (MDD) and post-stroke depression (PSD). MDD is thought to …
major depressive disorder (MDD) and post-stroke depression (PSD). MDD is thought to …