Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights
A Ragupathi, M Singh, AM Perez… - Frontiers in Cell and …, 2023 - frontiersin.org
BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA
metabolism, including homologous recombination and mediating the replication stress …
metabolism, including homologous recombination and mediating the replication stress …
[HTML][HTML] DNA and RNA quadruplex-binding proteins
V Brázda, L Hároníková, JCC Liao, M Fojta - International journal of …, 2014 - mdpi.com
Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and
Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i …
Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i …
BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
J Vohhodina, LJ Goehring, B Liu, Q Kong… - Nature …, 2021 - nature.com
R-loop structures act as modulators of physiological processes such as transcription
termination, gene regulation, and DNA repair. However, they can cause transcription …
termination, gene regulation, and DNA repair. However, they can cause transcription …
G4-quadruplex-binding proteins: review and insights into selectivity
V Meier-Stephenson - Biophysical reviews, 2022 - Springer
There are over 700,000 putative G4-quadruplexes (G4Qs) in the human genome, found
largely in promoter regions, telomeres, and other regions of high regulation. Growing …
largely in promoter regions, telomeres, and other regions of high regulation. Growing …
The complex genetic landscape of familial breast cancer
L Melchor, J Benítez - Human genetics, 2013 - Springer
Familial breast cancer represents a minor percentage of all human breast cancers.
Mutations in two high susceptibility genes BRCA1 and BRCA2 explain around 25% of …
Mutations in two high susceptibility genes BRCA1 and BRCA2 explain around 25% of …
Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening
Telomere overhangs are essential for telomere end protection and telomerase extension,
but how telomere overhangs are generated is unknown. Leading daughter strands …
but how telomere overhangs are generated is unknown. Leading daughter strands …
Telomerase regulation
C Cifuentes-Rojas, DE Shippen - Mutation research/Fundamental and …, 2012 - Elsevier
The intimate connection between telomerase regulation and human disease is now well
established. The molecular basis for telomerase regulation is highly complex and entails …
established. The molecular basis for telomerase regulation is highly complex and entails …
R-loops at chromosome ends: from formation, regulation, and cellular consequence
Y Gong, Y Liu - Cancers, 2023 - mdpi.com
Simple Summary R-loops, also referred to as RNA: DNA hybrids, are tripartite structures
formed when a single-stranded RNA molecule forms a complex with a double-stranded DNA …
formed when a single-stranded RNA molecule forms a complex with a double-stranded DNA …
[HTML][HTML] BRCA mutation carriers show normal ovarian response in in vitro fertilization cycles
M Shapira, H Raanani, B Feldman, N Srebnik… - Fertility and sterility, 2015 - Elsevier
Objective To evaluate the association between carriage of BRCA1/2 mutations and ovarian
performance, as demonstrated by in vitro fertilization (IVF) outcomes. Design Retrospective …
performance, as demonstrated by in vitro fertilization (IVF) outcomes. Design Retrospective …
Effects of BRCA1 and BRCA2 mutations on female fertility
Women with BRCA1/2 mutations have a significantly higher lifetime risk of developing breast
or ovarian cancer. We suggest that female mutation carriers may have improved fitness …
or ovarian cancer. We suggest that female mutation carriers may have improved fitness …