The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …

Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein
interactions. Understanding the role of the multiple structural and post-translational …

Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH< 5.8) and is thought
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …

Low molecular weight (LMW) thiols play an important role as thiol-cofactors for many
enzymes and are crucial to maintain the reduced state of the cytoplasm. Most Gram-negative …

Glyceraldehyde 3–phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme, which is
crucial for the breakdown of glucose to provide cellular energy. Over the past decade …

Coenzyme A (CoA) is a key cellular metabolite known for its diverse functions in metabolism
and regulation of gene expression. CoA was recently shown to play an important antioxidant …

Abstract Low-molecular-weight (LMW) thiols are produced in all living cells in different forms
and concentrations. Glutathione (GSH), coenzyme A (CoASH), bacillithiol (BSH), mycothiol …

Methyl parathion is an organophosphorus pesticide widely employed worldwide to control
pests in agricultural and domestic environments. However, due to its intensive use, high …

Coenzyme A (CoA) is an important cellular metabolite that is critical for metabolic processes
and the regulation of gene expression. Recent discovery of the antioxidant function of CoA …

Mycothiol (MSH) functions as major low molecular weight (LMW) thiol in the industrially
important Corynebacterium glutamicum. In this study, we genomically integrated an Mrx1 …