Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

New Findings What is the topic of this review? The manuscript collectively combines the
experimental observations from> 100 publications focusing on the regulation of cerebral …

Senescence is a leading cause of mortality, disability, and non‐communicable chronic
diseases in older adults. Mounting evidence indicates that the presence of cardiovascular …

Cerebral blood flow (CBF) is rigorously regulated by various powerful mechanisms to
safeguard the match between cerebral metabolic demand and supply. The question of how …

It has been well established in epidemiological studies and randomized controlled trials that
habitual exercise is beneficial for brain health, such as cognition and mental health …

The response of cerebral vasculature to exercise is different from other peripheral
vasculature; it has a small vascular bed and is strongly regulated by cerebral autoregulation …

Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial
pressure of arterial CO2 (PaCO2). This physiological response, termed cerebrovascular …

Regulation of the cerebral circulation relies on the complex interplay between
cardiovascular, respiratory, and neural physiology. In health, these physiologic systems act …

Cerebral autoregulation (CA) is integral to the delicate process of maintaining stable
cerebral perfusion and brain tissue oxygenation against changes in arterial blood pressure …

Blood flow (BF) increases with increasing exercise intensity in skeletal, respiratory, and
cardiac muscle. In humans during maximal exercise intensities, 85% to 90% of total cardiac …