Parkinson's disease (PD) is the most common neurological movement disorder
characterized by the selective and irreversible loss of dopaminergic neurons in substantia …

Lewy bodies that contain aggregated α‐synuclein in dopamine neurons are the main culprit
for neurodegeneration in Parkinson's disease. However, mitochondrial dysfunction has a …

Parkinson's disease and related synucleinopathies are characterized by the abnormal
accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of …

Neural tissue is one of the main oxygen consumers in the mammalian body, and a
plentitude of metabolic as well as signaling processes within the brain is accompanied by …

The accumulation of pathological α-synuclein (α-syn) in the central nervous system and the
progressive loss of dopaminergic neurons in the substantia nigra pars compacta are the …

Neurodegenerative diseases (NDDs) are irreversible, progressive diseases with no effective
treatment. The hallmark of NDDs is the aggregation of misfolded, modified proteins, which …

Abstract Development of neuroprotective therapeutics for Parkinson's disease (PD) is facing
a lack of translation from pre-clinical to clinical trials. One strategy for improvement is to …

An increasing number of the population all around the world suffer from age-associated
neurodegenerative diseases including Parkinson's disease (PD). This disorder presents …

Parkinson's disease, a progressive neurodegenerative disorder predominantly affecting
elderly, is marked by the gradual degeneration of the nigrostriatal dopaminergic pathway …

Mortalin is a chaperone protein that regulates physiological functions of cells. Its
multifactorial role allows cells to survive pathological conditions. Pharmacological, chemical …