[HTML][HTML] Adipose tissue and metabolic health

SM An, SH Cho, JC Yoon - Diabetes & Metabolism Journal, 2023 - synapse.koreamed.org
In this review, we provide a brief synopsis of the connections between adipose tissue and
metabolic health and highlight some recent developments in understanding and exploiting …

Latest advancements on combating obesity by targeting human brown/beige adipose tissues

R Pan, Y Chen - Frontiers in endocrinology, 2022 - frontiersin.org
Obesity is defined as overaccumulation of white adipose tissue in the body, mainly under the
skin (subcutaneous adiposity) or in the abdominal cavity (visceral adiposity). It could be the …

[HTML][HTML] Architecture of the outbred brown fat proteome defines regulators of metabolic physiology

H Xiao, LHM Bozi, Y Sun, CL Riley, VM Philip, M Chen… - Cell, 2022 - cell.com
Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all
mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has …

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

A Park, K Kim, I Park, SH Lee, KY Park, M Jung… - Nature …, 2023 - nature.com
Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of
generating heat via uncoupled respiration. Mitochondrial uncoupling protein 1 (UCP1) is …

[18F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue

J Levi, C Guglielmetti, TJ Henrich, JC Yoon… - Communications …, 2024 - nature.com
Brown and brown-like adipose tissues have attracted significant attention for their role in
metabolism and therapeutic potential in diabetes and obesity. Despite compelling evidence …

[HTML][HTML] Gochujang elicits anti-obesity effects by increasing capsaicin-independent brown adipogenesis and thermogenesis in high-fat diet induced obese mice

H Lee, J Song, S Chung, YS Cha, A Han - Journal of Functional Foods, 2023 - Elsevier
It is unknown whether Gochujang, a traditional Korean fermented food triggers thermogenic
energy expenditure. This study aims to investigate the impact of Gochujang on brown …

Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands

CMD Mota, CJ Madden - Nature Reviews Neuroscience, 2024 - nature.com
The mammalian brain controls heat generation and heat loss mechanisms that regulate
body temperature and energy metabolism. Thermoeffectors include brown adipose tissue …

[HTML][HTML] Protective effects of puerarin on metabolic diseases: Emphasis on the therapeutical effects and the underlying molecular mechanisms

Q Wan, S Luo, Q Lu, C Guan, H Zhang… - Biomedicine & …, 2024 - Elsevier
Metabolic diseases (MetD) such as diabetes mellitus, obesity, and hyperlipidemia have
become global health challenges. As a naturally occurring plant component, puerarin has …

LETMD1 regulates mitochondrial protein synthesis and import to guard brown fat mitochondrial integrity and function

M Snyder, YK Liu, R Shang, H Xu, C Thrift, X Chen… - Iscience, 2024 - cell.com
Thermogenic brown adipocytes (BAs) catabolize lipids to generate heat, representing
powerful agents against the growing global obesity epidemic. We and others reported …

LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis

Z Xing, M Du, Y Zhen, J Chen, D Li, R Liu, J Zheng - Cellular Signalling, 2023 - Elsevier
Atherosclerosis (AS), a metabolic disorder, is usually caused by chronic inflammation.
LETM1 Domain-Containing Protein 1 (LETMD1) is a mitochondrial outer membrane protein …