Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Gout is a crystal-deposition disease that results from chronic elevation of uric acid levels
above the saturation point for monosodium urate (MSU) crystal formation. Initial presentation …

Gout is the most common cause of inflammatory arthritis worldwide. In UK general practice,
the overall prevalence has increased from 1.4% in 1999 to 2.49% in 2012 [1], despite the …

Objectives To describe trends in the epidemiology of gout and patterns of urate-lowering
treatment (ULT) in the UK general population from 1997 to 2012. Methods We used the …

PURPOSE: The objective of this study was to estimate the latest prevalence of major
comorbidities associated with gout and hyperuricemia in the US based on a recent …

Gout is a crystal deposition disease that arises when supersaturation of body tissues with
urate occurs, leading to the formation of monosodium urate (MSU) crystals in and around …

Objective Existing criteria for the classification of gout have suboptimal sensitivity and/or
specificity, and were developed at a time when advanced imaging was not available. The …

Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant
properties that may be protective but can also be pro-oxidant, depending on its chemical …

Epidemiology is the study of the distribution and determinants of disease in human
populations. Over the past decade there has been considerable progress in our …

Objective: To develop evidence based recommendations for the management of gout.
Methods: The multidisciplinary guideline development group comprised 19 rheumatologists …