Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The
revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and …

Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …

We describe a touchscreen method that satisfies a proposed 'wish-list'of desirables for a
cognitive testing method for assessing rodent models of schizophrenia. A number of tests …

Zinc participation is essential for all physiological systems, including neural functioning,
where it participates in a myriad of cellular processes. Converging clinical, molecular, and …

The term neuroplasticity encompasses structural and functional modifications of neuronal
connectivity. Abnormal neuroplasticity is involved in various neuropsychiatric diseases, such …

Cortical information processing is under state-dependent control of subcortical
neuromodulatory systems. Although this modulatory effect is thought to be mediated mainly …

Background Accumulating evidence indicates that glutamatergic tone in schizophrenia may
vary as a function of illness duration or medication history. We conducted an exploratory …

Dopamine is one of the neurotransmitters whose transmission is altered in a number of
neural pathways in the brain of schizophrenic patients. Current evidence indicates that these …

Although our knowledge of the pathophysiology of schizophrenia has increased, treatments
for this devastating illness remain inadequate. Here, we critically assess rodent models and …

The etiology of psychiatric disorders remains largely unknown. The exploration of the
neurobiological mechanisms of mental illness helps improve diagnostic efficacy and …