Recent progress and prospects for anti-cytokine therapy in preclinical and clinical acute lung injury

GP Fadanni, JB Calixto - Cytokine & Growth Factor Reviews, 2023 - Elsevier
Acute respiratory distress syndrome (ARDS) is a heterogeneous cause of respiratory failure
that has a rapid onset, a high mortality rate, and for which there is no effective …

Statins in hospitalized COVID‐19 patients: A systematic review and meta‐analysis of randomized controlled trials

Y Ren, G Wang, D Han - Journal of Medical Virology, 2023 - Wiley Online Library
This systematic review and meta‐analysis aimed to determine the efficacy of statins in
hospitalized patients with coronavirus disease‐2019 (COVID‐19). A systematic search was …

Drug-Drug Interactions and the Clinical Tolerability of Colchicine Among Patients With COVID-19: A Secondary Analysis of the COLCORONA Randomized Clinical …

LS Alfehaid, S Farah, A Omer, BN Weber… - JAMA Network …, 2024 - jamanetwork.com
Importance Colchicine has many drug-drug interactions with commonly prescribed
medications. Only pharmacokinetic studies have provided data on colchicine drug-drug …

Prior statin vs in-hospital statin usage in severe COVID-19: review and meta-analysis

I Alhallak, H Paydak, JL Mehta - Current Problems in Cardiology, 2023 - Elsevier
Studies have shown that statins can decrease COVID-19 mortality in hospitalized patients.
This paper evaluates these studies and reviews the possible mechanism of how statins …

Edoxaban and/or colchicine in outpatients with COVID-19: rationale and design of the CONVINCE trial

A Landi, N Morici, P Vranckx, E Frigoli… - Journal of …, 2023 - journals.lww.com
Background An excessive inflammatory response and a hypercoagulable state are not
infrequent in patients with coronavirus disease-2019 (COVID-19) and are associated with …

Atorvastatin for reduction of 28-day mortality in severe and critical COVID-19 patients: a randomized controlled trial

NH Eltahan, NH Elsawy, KM Abdelaaty… - Respiratory …, 2024 - Springer
Background COVID-19 is an abnormal host response to the SARS-CoV-2 infection, which is
associated with endothelial dysfunction and multi-organ failure. Atorvastatin has been …

[HTML][HTML] Adapting power calculations to include a superiority margin: what are the implications?

S Bishara - Biochemia Medica, 2024 - hrcak.srce.hr
This paper examines the application of super-superiority margins in study power
calculations. Unlike traditional power calculations, which primarily aim to reject the null …

Oxygen Saturation in Hospitalized COVID-19 Patients and Its Relation to Colchicine Treatment: A Retrospective Cohort Study with an Updated Systematic Review

S Sharaf, R Ashmawy, E Saleh, M Salama… - Medicina, 2023 - mdpi.com
Background: Colchicine has been proposed as a cytokine storm-blocking agent for COVID-
19 due to its efficacy as an anti-inflammatory drug. The findings of the studies were …

A meta-analysis of randomized controlled trials of statin-based therapy in patients with COVID-19

G Kao, Y Chen, J Xiao, J Fan - International Journal of Clinical …, 2023 - search.proquest.com
Background: Previous observational studies and meta-analyses have suggested that statins
could be beneficial in reducing the risk of adverse clinical outcomes. This study is the first to …

[PDF][PDF] Lessons in biostatistics

S Bishara - Biochem Med (Zagreb), 2024 - biochemia-medica.com
This paper examines the application of super-superiority margins in study power
calculations. Unlike traditional power calculations, which primarily aim to reject the null …