Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by
absence of estrogen (ER) receptor, progesterone (PR) receptor, and human epidermal …

Innovative solutions are needed for the treatment of bacterial infections, and a range of
antibacterial molecules have been explored as alternatives to antibiotics. A different …

Recent advances in RNA delivery and target selection provide unprecedented opportunities
for cancer treatment, especially for cancers that are particularly hard to treat with existing …

Chemotherapy-induced neuropathic pain (CINP) is among the most common clinical
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …

Animal models are used to study many aspects of human disease and to test therapeutic
interventions. However, some very important features of human biology cannot be replicated …

Short interfering RNAs (siRNAs) are a valuable tool for gene silencing with applications in
both target validation and therapeutics. Many advances have recently been made to …

Immunotherapy, designed to exploit the functions of the host immune system against tumors,
has shown considerable potential against several malignancies. However, the utility of …

Breast cancer is the most frequently diagnosed malignancy in American women. While
significant progress has been made in the development of modern diagnostic tools and …

Formulations of cationic liposomes and polymers readily self-assemble by electrostatic
interactions with siRNA to form cationic nanoparticles which achieve efficient transfection …

For almost 30 years, studies have confirmed the effectiveness of cell-penetrating peptides
(CPPs) in the facilitation of the intracellular delivery of various cargo molecules, including …