Analytical characterization of liposomes and other lipid nanoparticles for drug delivery

Y Fan, M Marioli, K Zhang - Journal of pharmaceutical and biomedical …, 2021 - Elsevier
Lipid nanoparticles, especially liposomes and lipid/nucleic acid complexed nanoparticles
have shown great success in the pharmaceutical industry. Their success is attributed to …

Tailoring materials for modulation of macrophage fate

J Li, X Jiang, H Li, M Gelinsky, Z Gu - Advanced Materials, 2021 - Wiley Online Library
Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

T follicular helper cell biology: a decade of discovery and diseases

S Crotty - Immunity, 2019 - cell.com
Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

Antiviral potential of nanoparticles—can nanoparticles fight against coronaviruses?

S Gurunathan, M Qasim, Y Choi, JT Do, C Park… - Nanomaterials, 2020 - mdpi.com
Infectious diseases account for more than 20% of global mortality and viruses are
responsible for about one-third of these deaths. Highly infectious viral diseases such as …

Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health

CN Fries, EJ Curvino, JL Chen, SR Permar… - Nature …, 2021 - nature.com
Despite the overwhelming success of vaccines in preventing infectious diseases, there
remain numerous globally devastating diseases without fully protective vaccines, particularly …

[HTML][HTML] Induction of potent neutralizing antibody responses by a designed protein nanoparticle vaccine for respiratory syncytial virus

J Marcandalli, B Fiala, S Ols, M Perotti… - Cell, 2019 - cell.com
Respiratory syncytial virus (RSV) is a worldwide public health concern for which no vaccine
is available. Elucidation of the prefusion structure of the RSV F glycoprotein and its …

[HTML][HTML] Multifaceted effects of antigen valency on B cell response composition and differentiation in vivo

Y Kato, RK Abbott, BL Freeman, S Haupt, B Groschel… - Immunity, 2020 - cell.com
How antigen valency affects B cells in vivo during immune responses is not well understood.
Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated …

Bacterial outer membrane vesicles as a platform for biomedical applications: An update

M Li, H Zhou, C Yang, Y Wu, X Zhou, H Liu… - Journal of Controlled …, 2020 - Elsevier
Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and
in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and …

Synthetic nanoparticles for vaccines and immunotherapy

DJ Irvine, MC Hanson, K Rakhra, T Tokatlian - Chemical reviews, 2015 - ACS Publications
The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

From sewer to saviour—targeting the lymphatic system to promote drug exposure and activity

NL Trevaskis, LM Kaminskas, CJH Porter - Nature reviews Drug …, 2015 - nature.com
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …