Ex Vivo Culture of CTCs: An Emerging Resource to Guide Cancer Therapy

S Maheswaran, DA Haber - Cancer research, 2015 - AACR
With increasing application of targeted therapies and the development of acquired
resistance, much attention is being focused on developing in vitro and in vivo patient …

Recent advances in microfluidic methods in cancer liquid biopsy

FS Iliescu, DP Poenar, F Yu, M Ni, KH Chan, I Cima… - …, 2019 - pubs.aip.org
Early cancer detection, its monitoring, and therapeutical prediction are highly valuable,
though extremely challenging targets in oncology. Significant progress has been made …

Monolithic chip for high-throughput blood cell depletion to sort rare circulating tumor cells

F Fachin, P Spuhler, JM Martel-Foley, JF Edd… - Scientific reports, 2017 - nature.com
Circulating tumor cells (CTCs) are a treasure trove of information regarding the location, type
and stage of cancer and are being pursued as both a diagnostic target and a means of …

All-in-one centrifugal microfluidic device for size-selective circulating tumor cell isolation with high purity

A Lee, J Park, M Lim, V Sunkara, SY Kim… - Analytical …, 2014 - ACS Publications
Circulating tumor cells (CTCs) have gained increasing attention owing to their roles in
cancer recurrence and progression. Due to the rarity of CTCs in the bloodstream, an …

Microfluidic immunomagnetic cell separation from whole blood

SBN Gourikutty, CP Chang, PD Puiu - Journal of Chromatography B, 2016 - Elsevier
Immunomagnetic-based separation has become a viable technique for the separation of
cells and biomolecules. Here we report on the design and analysis of a simple and efficient …

A review on the use of microslit for various applications and its fabrication

T Majumder, PK Patowari - Journal of the Brazilian Society of Mechanical …, 2024 - Springer
Technological advancement, the high cost of energy, and the continuous growing demands
of multitasking devices are the driving forces behind the huge market of compact …

Microfluidic platform for negative enrichment of circulating tumor cells

BNG Sajay, CP Chang, H Ahmad, P Khuntontong… - Biomedical …, 2014 - Springer
Negative enrichment is the preferred approach for tumor cell isolation as it does not rely on
biomarker expression. However, size-based negative enrichment methods suffer from well …

Highlighting the uniqueness in dielectrophoretic enrichment of circulating tumor cells

F S. Iliescu, WJ Sim, H Heidari, D P. Poenar… - …, 2019 - Wiley Online Library
Circulating tumor cells (CTCs) play an essential role in the metastasis of tumors, and thus
can serve as a valuable prognostic factor for malignant diseases. As a result, the ability to …

An integrated on-chip platform for negative enrichment of tumour cells

SBN Gourikutty, CP Chang, DP Poenar - Journal of Chromatography B, 2016 - Elsevier
The study of cancer cells in blood, popularly called circulating tumour cells (CTCs), has
exceptional prospects for cancer risk assessment and analysis. Separation and enrichment …

Micro+ nanotexturing of substrates to enhance ligand-assisted cancer cell isolation

MAI Mahmood, Y Wan, M Islam, W Ali, M Hanif… - …, 2014 - iopscience.iop.org
This paper presents a simple approach to create a two-tiered surface for superior cancer cell
isolation. The idea is inspired by the interactions of cells with a nanotextured basement …