The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at
the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the …

Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …

Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety
of processes such as maintenance of cellular osmolarity and membrane potential, motility …

The use of local anesthetics during surgical treatment of cancer patients is an important part
of perioperative analgesia. In recent years, it has been showed that local anesthetics can …

Loss of epithelial polarity and gain in invasiveness by carcinoma cells are critical events in
the aggressive progression of cancers and depend on phenotypic transition programs such …

As the leading cause of death in cancer, there is an urgent need to develop treatments to
target the dissemination of primary tumor cells to secondary organs, known as metastasis …

Voltage-gated sodium channels (VGSCs) are transmembrane proteins which function as
gates that control the flux of ions across the cell membrane. They are key ion channels for …

Simple Summary Colorectal cancer is a major cause of morbidity and mortality that affects
men and women equally. Here, we present the role of voltage-gated sodium channels (NaV) …

Voltage-gated sodium (Na V) channels, initially characterized in excitable cells, have been
shown to be aberrantly expressed in non-excitable cancer tissues and cells from epithelial …

Voltage-gated sodium channels (VGSCs), which are abnormally expressed in various types
of cancers such as breast cancer, prostate cancer, lung cancer, and cervical cancer, are …