DNA nanotechnology has seen large developments over the last 30 years through the
combination of solid phase synthesis and the discovery of DNA nanostructures. Solid phase …

Circular dichroism (CD) spectroscopy is an optical technique that measures the difference in
the absorption of left and right circularly polarized light. This technique has been widely …

As the carrier of genetic information, the DNA double helix interacts with many natural
ligands during the cell cycle, and is amenable to such intervention in diseases such as …

Covering: 1980 to 2011 Major groove recognition of DNA by proteins utilizes the variation in
hydrogen bond donor/acceptor content that makes DNA base-pairs distinguishable from one …

Shortly after the discovery of the first antibiotics, bacterial resistance began to emerge. Many
mechanisms give rise to resistance; the most prevalent mechanism of resistance to the …

Isothermal titration calorimetry is a widely used biophysical technique for studying the
formation or dissociation of molecular complexes. Over the last 5 years, much work has …

This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

Despite their inherent toxicity and the acquired bacterial resistance that continuously
threaten their long-term clinical use, aminoglycosides (AGs) still remain valuable …

The alkaloid oxoglaucine (OG), which is a bioactive component from traditional Chinese
medicine (TCM), was synthesized by a two-step reaction and used as the ligand to react with …