Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …

Significance: Nonalcoholic fatty liver disease (NAFLD), characterized by liver triacylglycerol
build-up, has been growing in the global world in concert with the raised prevalence of …

The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables
the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might …

Reactive aldehydes arise as by-products of metabolism and are normally cleared by
multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes …

Genes mutated in patients with Fanconi anemia (FA) interact with the DNA repair genes
BRCA1 and BRCA2/FANCD1 to suppress tumorigenesis, but the molecular functions …

Covalent DNA–protein crosslinks (DPCs, also known as protein adducts) of topoisomerases
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …

Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to
life, and it can crosslink both DNA and proteins. However, the consequences of its …

The function of Fanconi anaemia proteins is to maintain genomic stability. Their main role is
in the repair of DNA interstrand crosslinks, which, by covalently binding the Watson and the …

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful
R loop accumulation, cells have evolved specific eukaryotic factors, one being the BRCA2 …