Recent studies show that alloantibodies mediate a substantial proportion of graft-rejection
episodes, contributing to both early and late graft loss. Rejection that is caused by antibody …

Alloantibodies to HLA class I or II and other antigens expressed by endothelium cause a
variety of effects on renal transplants, ranging from acute to chronic rejection, and even …

Solid organ transplantation is a curative therapy for hundreds of thousands of patients with
end-stage organ failure. However, long-term outcomes have not improved, and nearly half of …

Chronic allograft vasculopathy (CAV) in murine heart allografts can be elicited by adoptive
transfer of donor specific antibody (DSA) to class I MHC antigens and is independent of …

Longitudinal studies were conducted over a five-year period for HLA antibodies on 493 sera
tested from 54 kidney transplant patients. HLA single antigen beads were employed to …

Antibody-mediated rejection after liver transplantation is an under-recognised cause of
allograft injury. While definitions of acute and chronic antibody-mediated rejection have …

In the two and a half years following our initial paper on the humoral theory of
transplantation, many publications have emerged in support of the hypothesis, with no …

Until recently, allograft rejection was thought to be mediated primarily by alloreactive T cells.
Consequently, immunosuppressive approaches focused on inhibition of T cell activation …

Anti-HLA Abs have been shown to contribute to the process of transplant vasculopathy by
binding to HLA class I molecules expressed by the endothelial and smooth muscle cells of …

Major histocompatibility complex (MHC) molecules are well-known for their role in antigen
(cross-) presentation, thereby functioning as key players in the communication between …