Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies that target the
neuromuscular junction, leading to muscle weakness and fatigability. Currently available …

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation,
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …

Understanding the evolution of a protein, including both close and distant relationships,
often reveals insight into its structure and function. Fast and easy access to such up-to-date …

Muscle-specific kinase (MuSK) is essential for each step in neuromuscular synapse
formation. Before innervation, MuSK initiates postsynaptic differentiation, priming the muscle …

The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein
Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology …

Wnt signalling regulates multiple processes including angiogenesis, inflammation, and
tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like growth factor. Although …

Neuromuscular synapse formation depends upon coordinated interactions between motor
neurons and muscle fibers, leading to the formation of a highly specialized postsynaptic …

This article is part of a Minifocus on exploring the nucleus. For further reading, please see
related articles:'Integrating one-dimensional and threedimensional maps of genomes' by …

Yes-associated protein (Yap) is a major effector of the Hippo pathway that regulates cell
proliferation and differentiation during development and restricts tissue growth in adult …

The neuromuscular junction (NMJ) is the most extensively studied model of neuronal
synaptogenesis. Acetylcholine receptor (AChR) clustering on the postsynaptic membrane is …