Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

Moving from early studies, we here review the most recent evidence linking metabotropic
glutamate (mGlu) receptors to processes of neurodegeneration/neuroprotection. The use of …

Background: Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors
that mediate neuronal excitability and synaptic plasticity in the central nervous system, and …

(1) Background: Over the past 10 years, a number of scientific studies have demonstrated
the therapeutic potential of cannabinoid compounds present in the Cannabis Sativa and …

The amyloid β peptide (Aβ) is a central player in the neuropathology of Alzheimer's disease
(AD). The alteration of Aβ homeostasis may impact the fine-tuning of cell signaling from the …

In this study, we investigated the cross-talk between mGlu1 and CB1 receptors in
modulating GABA hippocampal output in whole-cell voltage clamp recordings in rat …

Type 1 spinocerebellar ataxia (SCA1) is a progressive neurodegenerative disorder with no
effective treatment to date. Using mice modeling SCA1, it has been demonstrated that a drug …

Metabotropic glutamate (mGlu) receptors represent the largest family of glutamate receptors
in mammals and act as fine tuners of the chemical transmission in central nervous system …

Cannabinoids (CBs) are implicated in a number of physiological and pathological
mechanisms in the central nervous system, but their exact role in post-ischemic brain injury …

Excitotoxicity plays a key role during insults to the developing brain such as neonatal
encephalopathy, stroke, and encephalopathy of prematurity. Such insults affect many …