Poly (ADP-ribose) polymerase inhibitors (PARPis) represent a therapeutic milestone in the
management of epithelial ovarian cancer. The concept of 'synthetic lethality'is exploited by …

The DNA double-strand break (DSB) repair factor 53BP1 has long been implicated in V (D) J
and class switch recombination (CSR) of mammalian lymphocyte receptors. However, the …

G0-G1 phase alternative end joining (A-EJ) is a recently defined mutagenic pathway
characterized by resected deletion and translocation joints that are predominantly direct and …

Tumor suppressor p53-binding protein 1 (53BP1) regulates DNA end joining in
lymphocytes, diversifying immune antigen receptors. This involves nucleosome-bound …

In B lymphocytes, class switch recombination (CSR) is an essential process that adapts
immunoglobulin (Ig) subtypes to antigen response. Taking place within the Ig heavy chain …

Small tandem DNA duplications in the range of 15 to 300 base‐pairs play an important role
in the aetiology of human disease and contribute to genome diversity. Here, we discuss …

Developing B and T lymphocytes requires programmed DNA double-strand breaks followed
by the activation of the DNA damage response (DDR) pathway and DNA repair. It is …

Secondary immunoglobulin diversification by somatic hypermutation and class switch
recombination in B cells is instrumental for an adequate adaptive humoral immune …

Acute onset of severe psychiatric symptoms or regression may occur in children with
premorbid neurodevelopmental disorders, although typically developing children can also …

Class switch recombination (CSR) represents one of the hallmark DNA transactions that
activated B cells execute during the generation of a humoral immune response to diversify …