Interplay between inflammation and thrombosis in cardiovascular pathology

K Stark, S Massberg - Nature Reviews Cardiology, 2021 - nature.com
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

[HTML][HTML] Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

R Bogeska, AM Mikecin, P Kaschutnig, M Fawaz… - Cell stem cell, 2022 - cell.com
Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system
following injury, such as following infection or inflammation. These challenges impair HSC …

Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

F Caiado, EM Pietras, MG Manz - Journal of Experimental Medicine, 2021 - rupress.org
Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Cell type-specific roles of NF-κB linking inflammation and thrombosis

M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

From haematopoietic stem cells to complex differentiation landscapes

E Laurenti, B Göttgens - Nature, 2018 - nature.com
The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells

B de Laval, J Maurizio, PK Kandalla, G Brisou… - Cell stem cell, 2020 - cell.com
Hematopoietic stem cells (HSCs) maintain life-long production of immune cells and can
directly respond to infection, but sustained effects on the immune response remain unclear …

Clonal analysis of lineage fate in native haematopoiesis

AE Rodriguez-Fraticelli, SL Wolock, CS Weinreb… - Nature, 2018 - nature.com
Haematopoiesis, the process of mature blood and immune cell production, is functionally
organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent …

Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis

AE Rodriguez-Fraticelli, C Weinreb, SW Wang… - Nature, 2020 - nature.com
Bone marrow transplantation therapy relies on the life-long regenerative capacity of
haematopoietic stem cells (HSCs),. HSCs present a complex variety of regenerative …