Peptide/protein-polymer conjugates make up a new class of soft matter comprising natural
and synthetic building blocks. They have the potential to combine the advantages of proteins …

Highlights•Chemoselective reactions enable site-specific PEGylation.•PEG-based
conformational stabilization provides enhanced proteolytic resistance.•PEG-based protein …

Nanotechnology holds the prospect for avant-garde changes to improve the performance of
materials in various sectors. The domain of enzyme biotechnology is no exception …

Protein stability remains one of the main factors limiting the realization of the full potential of
protein therapeutics. Poly (ethylene glycol)(PEG) conjugation to proteins has evolved into an …

Covalent conjugation of poly (ethylene glycol) or “PEGylation” has proven an effective
strategy to improve pharmaceutical protein efficacy by hindering recognition by proteases …

Recombinant human deoxyribonuclease I (rhDNase, Pulmozyme®) is the most frequently
used mucolytic agent for the symptomatic treatment of cystic fibrosis (CF) lung disease …

The effects of PEGylation on the structural, thermal and functional stability of bovine serum
albumin (BSA) were investigated using BSA and 6 linear mono-PEGylated BSA compounds …

The power and elegance of protein–polymer conjugates has solved many vexing problems
for society. Rational design of these complex covalent hybrids depends on a deep …

PEGylation of protein side chains has been used for more than 30 years to enhance the
pharmacokinetic properties of protein drugs. However, there are no structure-or sequence …

Hydrothermally stable and structrurally ordered mesoporous and microporous
aluminosilicates with different pore sizes have been synthesized to immobilize cytochrome c …