Antisense oligonucleotides (ASOs) are used to selectively inhibit the translation of disease-
associated genes via Ribonuclease H (RNaseH)-mediated cleavage or steric hindrance …

On binding to the cell surface receptor tyrosine kinase (TK) known as c-Met, hepatocyte
growth factor (HGF) stimulates mitogenesis, motogenesis, and morphogenesis in a wide …

Background: Metastasis is the primary cause of death in most human cancers, and
understanding the molecular mechanisms underpinning this multistep process is …

Decorin is not only a regulator of matrix assembly but also a key signaling molecule that
modulates the activity of tyrosine kinase receptors such as the epidermal growth factor …

Using recombinant bead-conjugated emerin, we affinity-purified seven proteins from HeLa
cell nuclear lysates that bind emerin either directly or indirectly. These proteins were …

Purpose Growth factor receptor-bound 2 (Grb2)-mediated HER2 signaling is thought to play
a critical role in gastric cancer development, progression and metastasis. However, little is …

Recent advances in understanding the kidney cancer gene pathways has provided the
foundation for the development of targeted therapeutic approaches for patients with this …

Background: Growth factor receptor-bound protein 2 (Grb2) is a 25 kDa adaptor protein,
which was originally discovered to accomplish basic cellular events such as cell growth, cell …

Sepia esculenta is a tasty and nutritious cephalopod. But the trend toward global warming is
accelerating with massive emissions of greenhouse gases. An increase in seawater …

MicroRNAs (miRNAs) are one class of short, endogenous RNAs which can regulate gene
expression at the post-transcriptional level. Previous analysis revealed that mammalian …