Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …

Trauma experienced during surgery can contribute to the development of a systemic
inflammatory response that can cause multi-organ dysfunction or even failure. Post-surgical …

Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …

In this narrative review, a theoretical framework on the crosstalk between physical exercise
and blood-brain barrier (BBB) permeability is presented. We discuss the influence of …

The blood–brain barrier (BBB) is formed by microvascular endothelial cells sealed by
tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs (TJ-associated …

Recovery from major depressive disorder is difficult, particularly in patients who are
refractory to antidepressant treatments. To examine factors that regulate recovery, we …

Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

Loss-of-function mutations of DNAJC6, encoding HSP40 auxilin, have recently been
identified in patients with early-onset Parkinson's disease (PD). To study the roles of …

The establishment of in vitro models of the BBB is significant for the evaluation of the
mechanism and permeability of drugs and their sustained-release formulations across the …