Polycystic ovary syndrome

AE Joham, RJ Norman, E Stener-Victorin… - The lancet Diabetes & …, 2022 - thelancet.com
Polycystic ovary syndrome (PCOS) affects 5–18% of women, and is a reproductive,
metabolic, and psychological condition with impacts across the lifespan. The cause is …

Progesterone actions and resistance in gynecological disorders

JA MacLean, K Hayashi - Cells, 2022 - mdpi.com
Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain
a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen …

Endometrial hyperplasia as a risk factor of endometrial cancer

LK Nees, S Heublein, S Steinmacher… - Archives of gynecology …, 2022 - Springer
Endometrial hyperplasia (EH) is the precursor lesion for endometrioid adenocarcinoma of
the endometrium (EC), which represents the most common malignancy of the female …

New concepts for an old problem: the diagnosis of endometrial hyperplasia

PA Sanderson, HOD Critchley… - Human reproduction …, 2017 - academic.oup.com
BACKGROUND Endometrial hyperplasia (EH) is a uterine pathology representing a
spectrum of morphological endometrial alterations. It is predominantly characterized by an …

Regression, relapse, and live birth rates with fertility-sparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: a systematic review and …

ID Gallos, J Yap, M Rajkhowa, DM Luesley… - American journal of …, 2012 - Elsevier
OBJECTIVE: The objective of the study was to evaluate the regression, relapse, and live
birth rates of early-stage endometrial cancer (EC) and atypical complex hyperplasia (ACH) …

Recent advance of small-molecule drugs for clinical treatment of osteoporosis: A review

JY Zhang, YH Zhong, LM Chen, XL Zhuo… - European journal of …, 2023 - Elsevier
Osteoporosis is a metabolic bone disorder typified by a reduction in bone mass and
structural degradation of bone tissue, leading to heightened fragility and vulnerability to …

Guideline no. 390-classification and management of endometrial hyperplasia

MH Auclair, PJ Yong, S Salvador, J Thurston… - Journal of obstetrics and …, 2019 - Elsevier
Objective The aim of this guideline is to aid primary care physicians and gynaecologists in
the initial evaluation of women with suspected endometrial hyperplasia, to recommend the …

Fertility‐sparing approach in patients with Endometrioid endometrial cancer grade 2 stage IA (FIGO): a qualitative systematic review

P Giampaolino, V Cafasso, D Boccia… - BioMed Research …, 2022 - Wiley Online Library
Background. Endometrial cancer (EC) is one of the most common gynecologic malignancy,
mostly in postmenopausal women. The gold standard treatment for EC is surgery, but in the …

Non-contraceptive benefits of hormonal and intrauterine reversible contraceptive methods

L Bahamondes, M Valeria Bahamondes… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Most contraceptive methods present benefits beyond contraception;
however, despite a large body of evidence, many healthcare professionals (HCPs), users …

Progesterone and endometrial cancer

A Gompel - Best practice & research Clinical obstetrics & …, 2020 - Elsevier
It is well established that unopposed estrogen, either endogenous or therapeutic, can
induce endometrial hyperplasia and potentially endometrial cancer (EC). Anovulatory …