Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …

5-Lipoxygenase (5-LOX) plays a key role in inflammation through the biosynthesis of
leukotrienes and other lipid mediators. Current evidence suggests that dietary (poly) …

Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …

The essential omega-3 fatty acid alpha-linolenic acid (ALA, 18: 3n3) can be converted into
EPA and DHA. The aim of the present study was to determine the effect of a high-ALA diet …

The phenolic profiles of extra virgin olive oils (EVOOs) may influence their cardiovascular
benefits. In a randomized crossover of acute EVOO intake on platelet function, participants …

Arachidonic acid-derived epoxyeicosatrienoic acids (EETs) are important regulators of
cardiac remodeling; manipulation of their levels is a potentially useful pharmacological …

The incidence, prevalence, and hospitalization rates associated with cardiovascular
diseases (CVDs) are projected to increase substantially in the world. Understanding of the …

Oxygenated lipids, called “oxylipins,” serve a variety of important signaling roles within the
cell. Oxylipins have been linked to inflammation and vascular function, and blood patterns …

Simple Summary Polyunsaturated fatty acids (PUFAs) and their derivatives, oxylipins, are a
constant focus of cancer research due to the relationship between cancer and processes of …

The biosynthetic crossover of 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2)
enzymatic activities is a productive pathway to convert arachidonic acid into unique …