Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
J Hu, PE Van den Steen, QXA Sang… - Nature reviews Drug …, 2007 - nature.com
Matrix metalloproteinases (MMPs) have outgrown the field of extracellular-matrix biology
and have progressed towards being important regulatory molecules in cancer and …
and have progressed towards being important regulatory molecules in cancer and …
Gelatinase B/MMP-9 in tumour pathogenesis and progression
AR Farina, AR Mackay - Cancers, 2014 - mdpi.com
Since its original identification as a leukocyte gelatinase/type V collagenase and tumour
type IV collagenase, gelatinase B/matrix metalloproteinase (MMP)-9 is now recognised as …
type IV collagenase, gelatinase B/matrix metalloproteinase (MMP)-9 is now recognised as …
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
RH Lee, AA Pulin, MJ Seo, DJ Kota, J Ylostalo… - Cell stem cell, 2009 - cell.com
Quantitative assays for human DNA and mRNA were used to examine the paradox that
intravenously (iv) infused human multipotent stromal cells (hMSCs) can enhance tissue …
intravenously (iv) infused human multipotent stromal cells (hMSCs) can enhance tissue …
Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9
RA Kowluru, Q Zhong, JM Santos - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Diabetic retinopathy remains one of the most feared complications of diabetes.
Despite extensive research in the field, the molecular mechanism responsible for the …
Despite extensive research in the field, the molecular mechanism responsible for the …
Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress
M Ikeda, T Ide, T Fujino, S Arai, K Saku, T Kakino… - PloS one, 2015 - journals.plos.org
Background Mitochondrial DNA (mtDNA) copy number decreases in animal and human
heart failure (HF), yet its role in cardiomyocytes remains to be elucidated. Thus, we …
heart failure (HF), yet its role in cardiomyocytes remains to be elucidated. Thus, we …
Abrogation of MMP-9 Gene Protects Against the Development of Retinopathy in Diabetic Mice by Preventing Mitochondrial Damage
OBJECTIVE In the development of diabetic retinopathy, mitochondrial dysfunction is
considered to play an important role in the apoptosis of retinal capillary cells. Diabetes …
considered to play an important role in the apoptosis of retinal capillary cells. Diabetes …
Matrix metalloproteinases and myocardial infarction
W Phatharajaree, A Phrommintikul… - Canadian Journal of …, 2007 - Elsevier
Acute myocardial infarction (AMI) is currently one of the most important health problems in
many countries around the world. Following AMI, many cytokines and proteolytic enzymes …
many countries around the world. Following AMI, many cytokines and proteolytic enzymes …
Comparison of matrix metalloproteinase 9 and 14 levels in vitreous samples in diabetic and non-diabetic patients: a case control study
A Ünal, O Baykal, N Öztürk - International journal of retina and vitreous, 2022 - Springer
Background MMP-9 plays a prominent role in inflammation and MMP-14 take part in
angiogenesis. The objective of this study is to compare MMP-9 and MMP-14 levels between …
angiogenesis. The objective of this study is to compare MMP-9 and MMP-14 levels between …
Protective effects of human pericyte-like adipose-derived mesenchymal stem cells on human retinal endothelial cells in an in vitro model of diabetic retinopathy …
G Lupo, A Agafonova, A Cosentino… - International Journal of …, 2023 - mdpi.com
Diabetic retinopathy (DR) is characterized by morphologic and metabolic alterations in
endothelial cells (ECs) and pericytes (PCs) of the blood–retinal barrier (BRB). The loss of …
endothelial cells (ECs) and pericytes (PCs) of the blood–retinal barrier (BRB). The loss of …
Helicobacter pylori Infection Acts Synergistically with a High-Fat Diet in the Development of a Proinflammatory and Potentially Proatherogenic Endothelial Cell …
A Krupa, W Gonciarz, P Rusek-Wala… - International journal of …, 2021 - mdpi.com
Classic atherosclerosis risk factors do not explain all cases of chronic heart disease. There
is significant evidence that gut microbiota may influence the development of atherosclerosis …
is significant evidence that gut microbiota may influence the development of atherosclerosis …