Cardiac alternans: mechanisms and clinical utility in arrhythmia prevention

K Kulkarni, FM Merchant, MB Kassab… - Journal of the …, 2019 - Am Heart Assoc
Sudden cardiac death (SCD) is frequently the initial manifestation of a cardiac arrhythmia,
resulting in about 350 000 deaths annually in the United States. 1 Devices such as the …

T-wave alternans as an arrhythmic risk stratifier: state of the art

FM Merchant, O Sayadi, K Moazzami, D Puppala… - Current cardiology …, 2013 - Springer
Microvolt level T-wave alternans (MTWA), a phenomenon of beat-to-beat variability in the
repolarization phase of the ventricles, has been closely associated with an increased risk of …

Advances in cardiac pacing: arrhythmia prediction, prevention and control strategies

MH Patel, S Sampath, A Kapoor, DN Damani… - Frontiers in …, 2021 - frontiersin.org
Cardiac arrhythmias constitute a tremendous burden on healthcare and are the leading
cause of mortality worldwide. An alarming number of people have been reported to manifest …

Comparative evaluation of methodologies for T-wave alternans mapping in electrograms

M Orini, B Hanson, V Monasterio… - IEEE Transactions …, 2013 - ieeexplore.ieee.org
Electrograms (EGM) recorded from the surface of the myocardium are becoming more and
more accessible. T-wave alternans (TWA) is associated with increased vulnerability to …

Cardiac contractility modulation in patients with heart failure—A review of the literature

G Bazoukis, A Saplaouras, P Efthymiou… - Heart Failure …, 2024 - Springer
Experimental in vivo and in vitro studies showed that electric currents applied during the
absolute refractory period can modulate cardiac contractility. In preclinical studies, cardiac …

Microvolt t-wave alternans is modulated by acute low-level tragus stimulation in patients with ischemic cardiomyopathy and heart failure

K Kulkarni, S Stavrakis, K Elkholey, JP Singh… - Frontiers in …, 2021 - frontiersin.org
Aims: Microvolt T-wave alternans (TWA), an oscillation in T-wave morphology of the
electrocardiogram (ECG), has been associated with increased susceptibility to ventricular …

Real-time closed-loop suppression of repolarization alternans reduces arrhythmia susceptibility in vivo

FM Merchant, O Sayadi, K Sohn, EH Weiss… - Circulation …, 2020 - Am Heart Assoc
Background: Repolarization alternans (RA) has been implicated in the pathogenesis of
ventricular arrhythmias and sudden cardiac death. Methods: We have developed a real …

An optimized method for estimating the tidal volume from intracardiac or body surface electrocardiographic signals: implications for estimating minute ventilation

O Sayadi, EH Weiss, FM Merchant… - American Journal …, 2014 - journals.physiology.org
The ability to accurately monitor tidal volume (TV) from electrocardiographic (ECG) signals
holds significant promise for improving diagnosis treatment across a variety of clinical …

A translational approach to probe the proarrhythmic potential of cardiac alternans: a reversible overture to arrhythmogenesis?

FM Merchant, O Sayadi, D Puppala… - American Journal …, 2014 - journals.physiology.org
Electrocardiographic alternans, a phenomenon of beat-to-beat alternation in cardiac
electrical waveforms, has been implicated in the pathogenesis of ventricular arrhythmias …

A novel method for determining the phase of T-wave alternans: diagnostic and therapeutic implications

O Sayadi, FM Merchant, D Puppala, T Mela… - Circulation …, 2013 - Am Heart Assoc
Background—T-wave alternans (TWA) has been implicated in the pathogenesis of
ventricular arrhythmias and sudden cardiac death. However, to estimate and suppress TWA …