Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells

U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

Genetics and epigenetics of gastroenteropancreatic neuroendocrine neoplasms

A Mafficini, A Scarpa - Endocrine reviews, 2019 - academic.oup.com
Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

[HTML][HTML] A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization …

G Rindi, DS Klimstra, B Abedi-Ardekani, SL Asa… - Modern Pathology, 2018 - Elsevier
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …

[HTML][HTML] An organoid biobank of neuroendocrine neoplasms enables genotype-phenotype mapping

K Kawasaki, K Toshimitsu, M Matano, M Fujita, M Fujii… - Cell, 2020 - cell.com
Gastroenteropancreatic (GEP) neuroendocrine neoplasm (NEN) that consists of
neuroendocrine tumor and neuroendocrine carcinoma (NEC) is a lethal but under …

Mixed neuroendocrine non-neuroendocrine neoplasms: a systematic review of a controversial and underestimated diagnosis

M Frizziero, B Chakrabarty, B Nagy, A Lamarca… - Journal of clinical …, 2020 - mdpi.com
Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare
diagnosis of the gastro-entero-pancreatic tract. Evidence from the current literature …

Digestive system mixed neuroendocrine-non-neuroendocrine neoplasms

L de Mestier, J Cros, C Neuzillet, O Hentic, A Egal… - …, 2017 - karger.com
Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) are a heterogeneous
subgroup of rare neoplasms that represent about a third of all poorly differentiated …

[HTML][HTML] Colorectal mixed adenoneuroendocrine carcinomas and neuroendocrine carcinomas are genetically closely related to colorectal adenocarcinomas

M Jesinghaus, B Konukiewitz, G Keller, M Kloor… - Modern Pathology, 2017 - Elsevier
Colorectal mixed adenoneuroendocrine carcinomas are rare and clinically aggressive
neoplasms with considerable morphological heterogeneity. Data on their genomic …

[HTML][HTML] New insights into the molecular characteristics of pulmonary carcinoids and large cell neuroendocrine carcinomas, and the impact on their clinical …

JL Derks, N Leblay, S Lantuejoul… - Journal of Thoracic …, 2018 - Elsevier
Carcinoids and large cell neuroendocrine carcinomas (LCNECs) are rare neuroendocrine
lung tumors. Here we provide an overview of the most updated data on the molecular …

Neuroendocrine neoplasia of the gastrointestinal tract revisited: towards precision medicine

G Rindi, B Wiedenmann - Nature Reviews Endocrinology, 2020 - nature.com
Over the past 5 years, a number of notable research advances have been made in the field
of neuroendocrine cancer, specifically with regard to neuroendocrine cancer of the …

Classification of neuroendocrine neoplasms: lights and shadows

S La Rosa, S Uccella - Reviews in endocrine and metabolic disorders, 2021 - Springer
Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplastic proliferations
showing different morphological features, immunophenotype, molecular background …