Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Tissue macrophages are immune cells whose phenotypes and functions are dictated by
origin and niches. However, tissues are complex environments, and macrophage …

INTRODUCTION High-density lipoprotein (HDL) participates in cholesterol homeostasis and
may also have anti-inflammatory or anti-microbial roles through its interaction with numerous …

Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

The molecular circadian clock regulates metabolic processes within the cell, and the
alignment of these clocks between tissues is essential for the maintenance of metabolic …

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and
a major cause of liver cirrhosis and hepatocellular carcinoma. NAFLD is intimately linked …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

We have previously demonstrated that iron overload in hepatic reticuloendothelial system
cells (RES) is associated with severe nonalcoholic steatohepatitis (NASH) and advanced …

Conclusions In a large Western cohort of patients with HCC, we found heterogeneous tumor
growth patterns, with one‐fourth exhibiting rapid growth and over one‐third having indolent …