Exploring innovative solutions to improve the healthcare of the aging and diseased
population continues to be a global challenge. Among a number of strategies toward this …

There have been numerous attempts to develop stem cell transplantation approaches to
promote the regeneration of spinal cord injury (SCI). Our multicenter team is currently …

For the past few decades, spinal cord injury (SCI) has been believed to be an incurable
traumatic condition, but with recent developments in stem cell biology, the field of …

Bipolar disorder (BP) and schizophrenia (SCZ) are major psychiatric disorders, but the
molecular mechanisms underlying the complicated pathologies of these disorders remain …

Neuronal loss and axonal demyelination underlie long-term functional impairments in
patients affected by brain disorders such as ischemic stroke. Stem cell-based approaches …

Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is
characterized by the degeneration of nigral dopaminergic (DA) neurons. While over 90% of …

A mutation in the chromatin remodeler chromodomain helicase DNA-binding 7 (CHD7)
gene causes the multiple congenital anomaly CHARGE syndrome. The craniofacial …

The risk of tumorigenicity is a hurdle for regenerative medicine using induced pluripotent
stem cells (iPSCs). Although teratoma formation is readily distinguishable, the malignant …

The generation of mature synaptic structures using neurons differentiated from human-
induced pluripotent stem cells (hiPSC-neurons) is expected to be applied to physiological …

Although neural stem/progenitor cells derived from human induced pluripotent stem cells
(hiPSC-NS/PCs) are expected to be a cell source for cell-based therapy, tumorigenesis of …