[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …

COVID-19: A review of therapeutic strategies and vaccine candidates

V Izda, MA Jeffries, AH Sawalha - Clinical Immunology, 2021 - Elsevier
The world is engulfed by one of the most widespread and significant public health crises in
decades as COVID-19 has become among the leading causes of death internationally. The …

[HTML][HTML] The aging lung: Physiology, disease, and immunity

JL Schneider, JH Rowe, C Garcia-de-Alba, CF Kim… - Cell, 2021 - cell.com
The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …

The total number and mass of SARS-CoV-2 virions

R Sender, YM Bar-On, S Gleizer… - Proceedings of the …, 2021 - National Acad Sciences
Quantitatively describing the time course of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for …

ACE2 expression is increased in the lungs of patients with comorbidities associated with severe COVID-19

BGG Pinto, AER Oliveira, Y Singh… - The Journal of …, 2020 - academic.oup.com
Patients who died from COVID-19 often had comorbidities, such as hypertension, diabetes,
and chronic obstructive lung disease. Although angiotensin-converting enzyme 2 (ACE2) is …

Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics

NR Cheemarla, TA Watkins, VT Mihaylova… - Journal of Experimental …, 2021 - rupress.org
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish
infection, and the replication level correlates with the likelihood of viral transmission. Here …

[HTML][HTML] COVID-19 and the human innate immune system

JL Schultze, AC Aschenbrenner - Cell, 2021 - cell.com
The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the
human population represents a tremendous medical and economic crisis. Innate immunity …

Vasculopathy in COVID-19

R Flaumenhaft, K Enjyoji… - Blood, The Journal of the …, 2022 - ashpublications.org
COVID-19 is a primary respiratory illness that is frequently complicated by systemic
involvement of the vasculature. Vascular involvement leads to an array of complications …

Potential interaction between SARS-CoV-2 and thyroid: a review

W Chen, Y Tian, Z Li, J Zhu, T Wei, J Lei - Endocrinology, 2021 - academic.oup.com
The novel coronavirus disease 2019 (COVID-19) produced by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is sweeping the world in a very short time. Although …

Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart

H Liu, S Gai, X Wang, J Zeng, C Sun… - Cardiovascular …, 2020 - academic.oup.com
Aims Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly binds to
ACE2 (angiotensin-converting enzyme 2) to facilitate cellular entry. Compared with the lung …