Pharmaceutical cocrystals, an important multi-component complex compressing at least two
molecules linked by noncovalent bonds within the same crystal lattice, have shown a great …

Co-crystal formation can improve the physicochemical properties of a compound, thus
enhancing its druggability. Therefore, artificial intelligence-based co-crystal virtual screening …

Tenoxicam (TNX) is a new non-steroidal anti-inflammatory drug that shows a superior anti-
inflammatory effect and has the advantages of a long half-life period, a fast onset of action, a …

It is well known that daidzein has various significant medicinal values and health benefits,
such as anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, cholesterol lowering …

Currently, cocrystallization is a promising strategy for tailoring the physicochemical
properties of active pharmaceutical ingredients. Theophylline, an alkaloid and the most …

Solvent-assisted grinding (SAG) and solution slow evaporation (SSE) methods are generally
used for the preparation of cocrystals. However, even by using the same solvent, active …

Abstract Lamotrigine (LAM), a Biopharmaceutics Classification System (BCS) class II drug, is
widely used to treat epilepsy, bipolar disorder and neuropathic pain. However, its low …

Three polymorphs (forms I, II and V) of isonicotinamide (INA) were mechanically flexible and
exhibited one-dimensional (1D) plasticity. Anisotropic intermolecular interactions contribute …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are class II biopharmaceutics classification
system drugs. The poor aqueous solubility of NSAIDs can lead to limited bioavailability after …

Two novel co-crystals of naproxen (NPX) were designed and prepared at a stoichiometric
ratio of 1: 1, namely, naproxen–caprolactam (NPX–CPL) and naproxen–oxymatrine (NPX …