Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …

Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility
of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here …

Biomaterials, biomedical devices and engineered cell grafts can be implanted to restitute
tissue anatomy and function. Such implants can either integrate physiologically, with no or …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic, chemoresistant
malignancy and is characterized by a dense, desmoplastic stroma that modulates PDAC …

Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here
we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) …

Cancer patients have a shorter life expectancy because of metastasis, which is the dynamic
chain of events that leads to the spread of tumour cells to distant places inside the body …

Multiphoton microscopy of cellular autofluorescence and second harmonic generation from
collagen facilitates imaging of living cells and tissues without the need for additional …

Cancer progression to metastatic dissemination is responsible for∼ 90% of deaths in
patients. Tremendous efforts have been made to understand primary tumor growth, cancer …