Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

Ribosomes interact with a variety of different protein biogenesis factors that guide newly
synthesized proteins to their native 3D shapes and cellular localization. Depending on the …

The dynamic ribosome–translocon complex, which resides at the endoplasmic reticulum
(ER) membrane, produces a major fraction of the human proteome,. It governs the synthesis …

The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum
membrane that is required for secretion of soluble proteins and production of many …

Mitochondria import nearly all of their approximately 1,000–2,000 constituent proteins from
the cytosol across their double-membrane envelope,,,–. Genetic and biochemical studies …

Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into
mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the …

Pichia pastoris has been recognized as an important platform for the production of various
heterologous proteins in recent years. The strong promoter AOX1, induced by methanol …

Background Tumor cells display augmented capability to maintain endoplasmic reticulum
(ER) homeostasis and hijack ER stress pathway for malignant phenotypes under …

The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation
in eukaryotic cells, responsible for production of secretory proteins and most integral …

The protein translocon at the endoplasmic reticulum comprises the Sec61 translocation
channel and numerous accessory factors that collectively facilitate the biogenesis of …