Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …

Objectives To systematically assess the efficacy and safety of IL-17 inhibitors in patients with
active ankylosing spondylitis. Methods A systematic review of the literature was performed …

Objectives To evaluate the efficacy and safety of risankizumab, a humanised monoclonal
antibody targeting the p19 subunit of interleukin-23 (IL-23), in patients with active ankylosing …

Background Ankylosing spondylitis (AS) shares many characteristics with inflammatory
bowel disease (IBD). Intestinal microbiota most likely plays an important role in the …

Objective To investigate the efficacy and safety of brodalumab, a fully human anti-interleukin-
17 receptor A monoclonal antibody, in patients with axial spondyloarthritis (axSpA). Methods …

Uveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies
(SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and …

Psoriasis is an immune-mediated inflammatory skin disease associated with numerous
inflammatory comorbidities, including increased cardiovascular risk. The interleukin (IL) …

Ankylosing spondylitis (AS) is a type of arthritis that is referred to a group of chronic immune-
mediated inflammatory diseases termed as seronegative spondyloarthropathies or …

Purpose: Approximately 10% of patients with mismatch repair–proficient (MMRp) colorectal
cancer showed clinical benefit to anti-PD-1 monotherapy (NCT01876511). We sought to …

Proinflammatory cytokines play an important role in the systemic and focal bone loss
associated with chronic inflammatory diseases. Targeting these cytokines with biologics and …