Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
A genomic timescale for placental mammal evolution
The precise pattern and timing of speciation events that gave rise to all living placental
mammals remain controversial. We provide a comprehensive phylogenetic analysis of …
mammals remain controversial. We provide a comprehensive phylogenetic analysis of …
Mammalian evolution of human cis-regulatory elements and transcription factor binding sites
Understanding the regulatory landscape of the human genome is a long-standing objective
of modern biology. Using the reference-free alignment across 241 mammalian genomes …
of modern biology. Using the reference-free alignment across 241 mammalian genomes …
Identification of constrained sequence elements across 239 primate genomes
Noncoding DNA is central to our understanding of human gene regulation and complex
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
DNA language models are powerful predictors of genome-wide variant effects
The expanding catalog of genome-wide association studies (GWAS) provides biological
insights across a variety of species, but identifying the causal variants behind these …
insights across a variety of species, but identifying the causal variants behind these …
The functional and evolutionary impacts of human-specific deletions in conserved elements
Conserved genomic sequences disrupted in humans may underlie uniquely human
phenotypic traits. We identified and characterized 10,032 human-specific conserved …
phenotypic traits. We identified and characterized 10,032 human-specific conserved …
Bayesian estimation of gene constraint from an evolutionary model with gene features
Measures of selective constraint on genes have been used for many applications, including
clinical interpretation of rare coding variants, disease gene discovery and studies of genome …
clinical interpretation of rare coding variants, disease gene discovery and studies of genome …
Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs
We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting
diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from …
diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from …
Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements
S Iñiguez-Muñoz, P Llinàs-Arias… - Cellular and Molecular …, 2024 - Springer
Discoveries in the field of genomics have revealed that non-coding genomic regions are not
merely" junk DNA", but rather comprise critical elements involved in gene expression. These …
merely" junk DNA", but rather comprise critical elements involved in gene expression. These …
[HTML][HTML] Comprehensive analyses of 435 goat transcriptomes provides insight into male reproduction
H Xu, S Zhang, Q Duan, M Lou, Y Ling - International Journal of Biological …, 2024 - Elsevier
A systematic analysis of genes related to reproduction is crucial for obtaining a
comprehensive understanding of the molecular mechanisms that underlie male reproductive …
comprehensive understanding of the molecular mechanisms that underlie male reproductive …